1. Mechanism and New

8. Lupus Erythematosus - Medication NSAIDs may be used for musculoskeletal and mild systemic complaints, although ibuprofen has been noted to cause an aseptic meningitis in a small number of patients with SLE. Patients with mainly arthritic symptoms may be treated with weekly methotrexate, PO or SC Hydroxychloroquine often used to help control cutaneous manifestations, and is now the mainstay of SLE therapy Steroids often necessary to control systemic and renal manifestations Patients with renal disease often need immunosuppressive agents, such as cyclophosphamide (usually given as monthly IV boluses). Mycophenolate mofetil, cyclosporin, or azathioprine may also be used.

9. Lupus Erythematosus - Medication Patients with antiphospholipid antibodies are often treated with a baby aspirin daily. If they have already had a significant clotting event, they need stronger anticoagulation. Angiotensin converting enzyme inhibitors are often used to help prevent renal damage from proteinuria. Rituximab (anti-CD20 antibody) causes B-cell depletion and is now being used in SLE, especially for thrombocytopenia. Other biologic agents also being tested in lupus (e.g., antibodies to CD40 and C5)

11. Treatment of Proliferative Lupus Nephritis

12. Quality Measures for SLE