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HCMV Infection of Humanized Mice after Transplantation of G-CSF–Mobilized Peripheral Blood Stem Cells from HCMV-Seropositive Donors  Morgan Hakki, Devorah.

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Presentation on theme: "HCMV Infection of Humanized Mice after Transplantation of G-CSF–Mobilized Peripheral Blood Stem Cells from HCMV-Seropositive Donors  Morgan Hakki, Devorah."— Presentation transcript:

1 HCMV Infection of Humanized Mice after Transplantation of G-CSF–Mobilized Peripheral Blood Stem Cells from HCMV-Seropositive Donors  Morgan Hakki, Devorah C. Goldman, Daniel N. Streblow, Kimberly L. Hamlin, Craig N. Krekylwich, William H. Fleming, Jay A. Nelson  Biology of Blood and Marrow Transplantation  Volume 20, Issue 1, Pages (January 2014) DOI: /j.bbmt Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Engraftment of NSG mice after transplantation of G-CSF–mobilized PBSCs. (A) Representative donor lineage analysis in xenografts. Flow cytometry of splenocytes from a mouse undergoing transplantation with PBSCs from donor 2 is shown. (B-D) Peripheral blood (B), bone marrow (C), and splenocytes (D) from mice undergoing transplantation with PBSCs from donors 2, 3, and 4 were analyzed at the time of tissue harvest for engraftment of human cell populations. Donor 1 human CD45+ engraftment was <0.5% in all mice. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions


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