1. Closing Cancer Cases Not Under Active Care
Angela Douglas MBE
Clinical Programme Director
NW Coast Genomic Medicine Centre

2. Return of Results in Portal / Close Cases in Portal
Not Validated
Scientist/Clinician Identification of relevant genes/variants clinical trials
Genomic MDT Group
Validation
Integrated report
Tumour specific MDT
Other diagnostic tests
Clinical Discussion with patient about further treatment
Relevant Results to patient
Through follow up /when relapsed
Results to clinician for review
Decision about treatment
Patient treatment

3. Presentation at MDT

4. Information for MDT Prepared by Scientist in collaboration with Clinician or Recruitment Nurse
Patient:
DOB:
NHS No:
Hospital No:
Hospital Name:
Consultant:
Cancer Type:
Subtype:
Participant ID:
Deceased:
Patient is/ is not currently on an active pathway FF
Not FFPE

5. List domain 1 somatic variants identified in report and highlight any relevant to patient
List domain 2 somatic variants highlight any relevant to patient
Highlight any pertinent structural variants of cancer genes
Highlight any pertinent germline cancer susceptibility variants that were identified
Number of somatic non-synonymous SNVs per megabase (coding region): x = ? =/ Not HIGH TMB

6. Mutation signature FF Not FFPE aetiology remains unknown
likely due to tobacco mutagens
? deficient relevant signature

7. GTAB Decision outcome Following Discussion
Outcomes from MDT: NO validation required at present patient has not reoccurred

8. Return of Results in Portal / Close Cases in Portal
Not Validated
Scientist/Clinician Identification of relevant genes/variants clinical trials
Genomic MDT Group
Validation
Integrated report
Tumour specific MDT
Other diagnostic tests
Clinical Discussion with patient about further treatment
Relevant Results to patient
Through follow up /when relapsed
Results to clinician for review
Decision about treatment
Patient treatment