1. Childhood undernutrition, the gut microbiota, and microbiota-directed therapeutics
by Laura V. Blanton, Michael J. Barratt, Mark R. Charbonneau, Tahmeed Ahmed, and Jeffrey I. Gordon
Science
Volume 352(6293):
June 24, 2016
Published by AAAS

2. The concept that impaired postnatal gut microbiota development (maturation) is causally related to childhood undernutrition.
The concept that impaired postnatal gut microbiota development (maturation) is causally related to childhood undernutrition. The representation of age-discriminatory bacterial taxa defines a program of normal gut microbiota development. Disrupting the coordinated functional codevelopment of microbiota and host affects multiple biological regulatory systems through largely unknown mechanisms. Developing effective strategies for sustained repair of microbiota immaturity though food or microbial interventions requires preclinical studies of these mechanisms and modeling of the effects of different rates and routes of repair.
Laura V. Blanton et al. Science 2016;352:1533
Published by AAAS