1. Volume 21, Issue 1, Pages 20-23 (July 2011)
The Impact of Developmental Biology on Pluripotent Stem Cell Research: Successes and Challenges 
Janet Rossant 
Developmental Cell 
Volume 21, Issue 1, Pages (July 2011)
DOI: /j.devcel
Copyright © 2011 Elsevier Inc. Terms and Conditions

2. Figure 1 Origins of Mouse and Human Pluripotent Cells
During early mouse development, the inner cell mass (ICM) of the blastocyst can generate ES cells, while Epi-SCs can be derived from the epiblast of the early postimplantation embryo and from the blastocyst ICM. In contrast, cells from the human ICM share properties of both ES cells and Epi-SCs, and true Epi-SCs have not yet been derived from the human epiblast. At later stages, the PGCs of both mice and humans can be used to generate pluripotent cells, although the relationship between mouse EGCs, which can be converted into an ES cell-like state, and the EGC-like cells derived from humans remains unclear. Finally, the adult cells of both mice and humans can be reprogrammed into pluripotent iPSCs.
Developmental Cell  , 20-23DOI: ( /j.devcel )
Copyright © 2011 Elsevier Inc. Terms and Conditions