1. M2D2 Connect the Resources of the University of Massachusetts to Medical Device firms within Massachusetts 26 UMass Lowell and 18 UMass Worcester Faculty Steering Committee – 24 Investment and Industry Leaders M2D2 Massachusetts Medical Device Development Center UMass Lowell & Worcester M2D2 WorkforceTraining ProductRealizationProcess Incubators/Facilities BusinessRealizationProcess Worcester

2. M2D2 Resources Assistance with: –Defining Market & Business Opportunity –Prototype Development –Clinical Trials Assistance Funding Grant Development, Loans, Investors Space Wet/Dry Labs, Office Networks of People & Resources

3. M2D2 Successful Funding Efforts - NIH SBIR/STTR $150,000 8 proposals submitted 60% success $2.2MM (ROI > 10 x) A.Develop a Winning Proposal / Electronic Application B.Experts and Facilities to Insure Success 1. VasoTech Worcester - Lowell, MA $1.2 Million Biodegradable Polymer Drug Eluting Stent 2. Vista Scientific Lawrence, MA $318,000 Nanosphere-Antibiotic Corneal Contact Lens 3. Source Production Andover, MA $500,000 Brachytherapy for Lung Cancer 4. Kazak Woburn, MA $100,000 Portable Jaws of Life 5. Aragon Lowell, MA $100,000 Neuromuscular Biosensor Worcester

4. M2D2 Matching FastLane Loan Fund $500,000 JAII Project Award up to $150K/company A.Business Assessment / Medical Assessment (15) B.Prototype / Manufacture / Animal & Clinical Trials / IP / FDA (5) Worcester Aura Medsystems Lowell, MA Photochemical Tissue Bonding Oz Technologies Springfield, MA User Friendly Pessary Smart Surfaces Worcester, MA Ulcer Prevention Mattress MedicaMetrix Wayland, MA Prostate Measurement MoMelan Cambridge, MA Expanded Skin Grafting

5. Aura MedSystems Photochemical Tissue Bonding Mass Life Sciences Accelerator Grant M2D2 FastLane Fig. 3: Patient 20 (lower abdomen) 2 weeks6 months PTB sutures

6. Vista A. Topical Ophthalmic Drug Delivery Device B. Nanosphere – Antibiotic Corneal Contact Lens $1,600,000 NIH SBIR Grant ABAB

7. VasoTech Biodegradable Drug Eluting Stent $1,200,000 NIH STTR

8. SafePath Safety Suture Needle Eliminates accidental needle stick injuries in hospitals.

9. CMB Biosciences Electrospun Silk Bandage for Burns

10. Nano BPS Miniature Fiber Optic Blood Pressure Sensor Coronary angiography following introduction of the UML fiber pressure sensor into the LAD.

11. Smart Surfaces Reactive Mattress to Prevent Pressure Ulcers M2D2 FastLane Award

12. MedicaMetrix ProstaGlove – Prostate Measurement M2D2 FastLane Award

13. Dartmouth Medical BIODEGRADABLE CRANIOMAXILLOFACIAL BONDING SYSTEM

14. Worcester M2D2 M2D2 Facilities / Incubator Regional Innovation Center $4 Million Capital Commitment Gov. Deval Patrick and Sen. Steven Panagiotakos Help Establish Innovation Center at UMass Lowell

15. Worcester M2D2 M2D2 Facilities / Incubator Regional Innovation Center 1.Wannalancit Mill- 1 st Floor – Office / Conference (6K s.f.) 2.333 Aiken St. - Shared Wet Lab Space (6,000 sq ft.) 3. Wannalancit Mill – 2 nd Floor- New Offices / Labs / Conf. (15,000 sq. ft.) - Spring 2011

16. Worcester M2D2 M2D2 Steering Committee Industry Focused & Engaged