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Polyethylene glycol–modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency  Raz Somech, MD,

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Presentation on theme: "Polyethylene glycol–modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency  Raz Somech, MD,"— Presentation transcript:

1 Polyethylene glycol–modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency  Raz Somech, MD, Yew Hon Lai, MD, Eyal Grunebaum, MD, Nicole Le Saux, MD, Ernest Cutz, MD, Chaim M. Roifman, MD  Journal of Allergy and Clinical Immunology  Volume 124, Issue 4, Pages (October 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A, Hematoxylin and eosin stain of the patient's lung biopsy specimen demonstrating diffuse interstitial goblet cell hyperplasia, as well as dense inflammatory infiltrates consisting of plasma cells, eosinophils, and lymphocytes. Immunohistochemical staining detected mainly CD8+ T cells (B), CD20+ B cells (C), and mast cells (D). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 A, Hematoxylin and eosin stain of the patient's liver biopsy specimen demonstrating hepatocyte swelling and clusters of inflammatory cells. B, Trichrome stain shows increased portal and periportal fibrosis. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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