Presentation is loading. Please wait.

Presentation is loading. Please wait.

Diffuse large B-cell lymphoma as presenting feature of Zap-70 deficiency  Andrea Newell, BSc, Harjit Dadi, PhD, Rachel Goldberg, BSc, Bo-Yee Ngan, MD,

Published byRolf Maxwell Modified over 5 years ago

Similar presentations

Presentation on theme: "Diffuse large B-cell lymphoma as presenting feature of Zap-70 deficiency  Andrea Newell, BSc, Harjit Dadi, PhD, Rachel Goldberg, BSc, Bo-Yee Ngan, MD,"— Presentation transcript:

1 Diffuse large B-cell lymphoma as presenting feature of Zap-70 deficiency 
Andrea Newell, BSc, Harjit Dadi, PhD, Rachel Goldberg, BSc, Bo-Yee Ngan, MD, Eyal Grunebaum, MD, Chaim M. Roifman, MD  Journal of Allergy and Clinical Immunology  Volume 127, Issue 2, Pages (February 2011) DOI: /j.jaci Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A, Diffuse large B-cell lymphoma, immunoblastic, hematoxylin and eosin stain. Diffuse infiltration and effacement of the lymph node parenchyma by a monomorphous diffuse large cell infiltrate. Many of these cells have a centrally placed prominent nucleolus and amphophilic cytoplasm (a feature of neoplastic immunoblasts). B, Moderate nuclear proliferative index (60% to 70%) as indicated by the number of positive nuclear stained lymphoma large cells by the nuclear proliferation protein Mib-1. C, Lymphoma cells express pan B-cell antigen CD20. D, Lymphoma cells do not express germinal center B-cell nuclear protein BCL6. E, Neither the lymphoma B cells nor the reactive T cells express Zap-70 cytoplasmic protein. F, Zap-70 staining in a control lymph node section. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Molecular analysis of Zap70. A, Sequence chromatogram of a normal control. Region shown is the 3’ boundary of exon 5 and the flanking intronic sequence. B, Sequence chromatogram of the patient. The same region as in A is shown. A vertical arrow indicates the position at which the deletion occurs. C, Zap70 protein schematic. The amino-terminal Src homology 2 (SH2) domain, interdomain A, carboxy-terminal SH2 domain, interdomain B, and the kinase domain are shown in cyan, yellow, blue, red, and orange, respectively. A vertical arrow indicates the putative position of the deletion within interdomain B. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Diffuse large B-cell lymphoma as presenting feature of Zap-70 deficiency  Andrea Newell, BSc, Harjit Dadi, PhD, Rachel Goldberg, BSc, Bo-Yee Ngan, MD,"

Similar presentations

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,
Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O
Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD 

Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD 
Defects of class-switch recombination

Defects of class-switch recombination
BCG-osis and tuberculosis in a child with chronic granulomatous disease  Jacinta Bustamante, MD, PhD, Guzide Aksu, MD, Guillaume Vogt, PhD, Ludovic de.

BCG-osis and tuberculosis in a child with chronic granulomatous disease  Jacinta Bustamante, MD, PhD, Guzide Aksu, MD, Guillaume Vogt, PhD, Ludovic de.
Obstructive sleep apnea syndrome and inflammation

Obstructive sleep apnea syndrome and inflammation
Advances in food allergy in 2015

Advances in food allergy in 2015
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Ann-Marie M. Schoos, MD, PhD, Jacob D

Ann-Marie M. Schoos, MD, PhD, Jacob D
Taco W. Kuijpers, MD, PhD, Paul A. Baars, PhD, Daan J

Taco W. Kuijpers, MD, PhD, Paul A. Baars, PhD, Daan J
Long-term immune reconstitution after matched unrelated hematopoietic stem cell transplantation for immunodeficiency  Vy Hong-Diep Kim, MD, Brenda Reid,

Long-term immune reconstitution after matched unrelated hematopoietic stem cell transplantation for immunodeficiency  Vy Hong-Diep Kim, MD, Brenda Reid,
Is 9 more than 2 also in allergic airway inflammation?

Is 9 more than 2 also in allergic airway inflammation?
Pathergy response to skin prick testing

Pathergy response to skin prick testing
Ζ Chain–associated protein of 70 kDa (ZAP70) deficiency in human subjects is associated with abnormalities of thymic stromal cells: Implications for T-cell.

Ζ Chain–associated protein of 70 kDa (ZAP70) deficiency in human subjects is associated with abnormalities of thymic stromal cells: Implications for T-cell.
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
Polyethylene glycol–modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency  Raz Somech, MD,

Polyethylene glycol–modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency  Raz Somech, MD,
The Wiskott-Aldrich syndrome

The Wiskott-Aldrich syndrome
Tertiary lymphoid organs in recalcitrant chronic rhinosinusitis

Tertiary lymphoid organs in recalcitrant chronic rhinosinusitis
Anaphylactic reaction to (mixed) fruit juice containing dragon fruit

Anaphylactic reaction to (mixed) fruit juice containing dragon fruit

Similar presentations

Ads by Google