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A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy  Justin M. Skripak, MD, Scott D. Nash, MD, Hannah.

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Presentation on theme: "A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy  Justin M. Skripak, MD, Scott D. Nash, MD, Hannah."— Presentation transcript:

1 A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy  Justin M. Skripak, MD, Scott D. Nash, MD, Hannah Rowley, RD, Nga H. Brereton, RD, Susan Oh, RD, Robert G. Hamilton, PhD, Elizabeth C. Matsui, MD, A. Wesley Burks, MD, Robert A. Wood, MD  Journal of Allergy and Clinical Immunology  Volume 122, Issue 6, Pages (December 2008) DOI: /j.jaci Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Study timeline. Key features and overall timeframe are shown. OFC, Oral food challenge. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Change in milk dose threshold. A, Threshold change in active group (P = .002). B, Threshold change in placebo group (P = .16). Change in threshold after open-label active treatment in the placebo group is also shown in Fig 2, B (from after placebo to after milk OIT). Change in threshold for active versus placebo groups, P = Orange bars represent medians. MOIT, Milk OIT. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Change in end-point titration skin prick testing. A, Threshold change in active group (P = .03). B, Threshold change in placebo group (P = .03). Change in threshold for active versus placebo groups, P = .54. Orange bars represent medians. MOIT, Milk OIT. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Change in milk-specific IgE levels. Results are shown before milk OIT (MOIT), at maintenance, and after MOIT for the active group (P = .75; A) and placebo group (P = .46; B). Change in threshold for active versus placebo groups, P = .87. Orange bars represent medians. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 Change in milk-specific IgG4 levels. Results are shown before milk OIT (MOIT), at maintenance, and after MOIT for the active group (P = .002; A) and placebo group (P = .6; B). Change in threshold for active versus placebo groups, P = Orange bars represent medians. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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