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Prognostic Significance of the Tumor Suppressor Gene Maspin in Non–Small Cell Lung Cancer  Kyoji Hirai, MD, Kiyoshi Koizumi, MD, Shuji Haraguchi, MD,

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Presentation on theme: "Prognostic Significance of the Tumor Suppressor Gene Maspin in Non–Small Cell Lung Cancer  Kyoji Hirai, MD, Kiyoshi Koizumi, MD, Shuji Haraguchi, MD,"— Presentation transcript:

1 Prognostic Significance of the Tumor Suppressor Gene Maspin in Non–Small Cell Lung Cancer 
Kyoji Hirai, MD, Kiyoshi Koizumi, MD, Shuji Haraguchi, MD, Tomomi Hirata, MD, Iwao Mikami, MD, Mitsuhiro Fukushima, MD, Shigeki Yamagishi, MD, Tetsuo Kawashima, MD, Daisuke Okada, MD, Kazuo Shimizu, MD, Masashi Kawamoto, MD  The Annals of Thoracic Surgery  Volume 79, Issue 1, Pages (January 2005) DOI: /j.athoracsur Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Immunohistochemical staining patterns for maspin and p53 in non–small cell lung cancer and normal lung tissue. (A) Weak immunostaining for maspin surrounding the nucleus of bronchial gland epithelial cells in normal lung tissue and negative staining in normal alveolar epithelial cells (magnification, ×200). (B, C) Strong immunostaining for maspin in cytoplasm of adenocarcinoma and squamous cell carcinoma, and negative staining of stromal cells (magnification, ×200). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Reverse transcription–polymerase chain reaction analysis of maspin and β-actin messenger ribonucleic acid in normal lung tissues and cancer tissues of 3 different patients. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 (A) Maspin/β-actin ratio from semiquantification of reverse transcription–polymerase chain reaction products in normal tissues and cancer tissues (mean ± standard deviation). (B) Comparative tumor/nontumor (T/N) ratios for maspin messenger ribonucleic acid (mean ± standard deviation) in stage I (n = 15), stage II (n = 10), and stage III (n = 15). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Kaplan-Meier survival of non–small cell lung cancer patients on the basis of maspin immunoreactivity using the Wilcoxon statistic. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

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