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Association of p53 Codon 72 Genotypes and Clinical Outcome in Human Papillomavirus-Infected Lung Cancer Patients  Shih-Pin Chen, MD, Nan-Yung Hsu, MD,

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Presentation on theme: "Association of p53 Codon 72 Genotypes and Clinical Outcome in Human Papillomavirus-Infected Lung Cancer Patients  Shih-Pin Chen, MD, Nan-Yung Hsu, MD,"— Presentation transcript:

1 Association of p53 Codon 72 Genotypes and Clinical Outcome in Human Papillomavirus-Infected Lung Cancer Patients  Shih-Pin Chen, MD, Nan-Yung Hsu, MD, PhD, Jeng-Yuan Wu, MD, PhD, Chih-Yi Chen, MD, Ming-Chih Chou, MD, PhD, Huei Lee, PhD, Ya-Wen Cheng, PhD  The Annals of Thoracic Surgery  Volume 95, Issue 4, Pages (April 2013) DOI: /j.athoracsur Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 The representative reciprocal relationships between human papillomavirus (HPV)16 or HPV18 E6 and p53 immunostainings in serial paraffin sections of lung tumors. Immunoreactivity was detected by immunoperoxidase-diaminobenzidine with hematoxylin counter stain. Note immunoreactivity (brown color) showing in the nuclei. (B) and (C) show HPV 16 E6 and p53 positive immunostaining in the nuclei; (A) and (B), (C) and (D), 2 serial sections from the same lung tumors. (A) p53 immunostaining–positive; (B) HPV16 E6 immunostaining–positive; (C) p53 immunostaining–positive; (D) HPV16 E6 immunostaining–negative. In (A) and (B) the bars = 100 micrometers. In (C) and (D) bars = 200 micrometers. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Kaplan-Meier analysis for the influence of (A) tumor stage; (B) human papillomavirus (HPV) 16/18 E6; (C) p53 codon 72 polymorphism; and (D) both combinations in all study subjects. (Arg = arginine; Pro = proline.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Kaplan-Meier analysis for the influence of 53 codon 72 polymorphism in (A) HPV 16/18 E6 negative, (B) HPV 16 E6 negative, and (C) HPV 18 E6 negative patients; and in (D) HPV 16/18 E6 positive, (E) HPV 16 E6 positive, and (F) HPV 16 E6 positive patients. (Arg = arginine; HPV = human papillomavirus; Pro = proline.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

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