1. Predicted and observed HbA1c levels using doubly robust estimation adjusting for either a comprehensive set of confounders (left panel) or a set of confounders provided by a domain expert (right panel).
Predicted and observed HbA1c levels using doubly robust estimation adjusting for either a comprehensive set of confounders (left panel) or a set of confounders provided by a domain expert (right panel). Red dots indicate the actual measurements of patients at baseline (before second-line treatment), after 6 and 12 months. Black dots (with error bars) represent the counterfactual predictions and 95% CIs, supposing all patients were treated with that drug class. The results of the Bayesian mixed-treatment comparison (MTC) meta-analysis by McIntosh et al 7 8 are marked MTC. DPP-4, dipeptidyl peptidase 4; GLP-1, glucagon-like peptide-1 receptor agonists; HbA1c, glycated hemoglobin; SU, sulfonylurea; TZD, thiazolidinedione.
Assaf Gottlieb et al. BMJ Open Diab Res Care 2017;5:e000435
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