1. CHARLIE L. CLARK, EA Pesticide Registration Review Section (PRRS)
Bureau of Scientific Evaluation and Technical Assistance (BSETA)
Division of Agricultural Environmental Services (AES)
Florida Department of Agriculture & Consumer Services (FDACS)
(850)
2/22/2019

2. FEDERAL LAWS & RULES
Federal Insecticide Fungicide & Rodenticide Act (FIFRA)
Federal Food, Drug and Cosmetic Act (FFDCA); as amended by
Food Quality Protection Act (FQPA)
40 Code of Federal Regulations (CFR), Parts

3. Federal Pesticide Registration
All pesticides must be registered by USEPA
USEPA reviews information and data from >120 studies and conducts risk assessments and risk mitigation prior to registration
Pesticide label instructions = primary mechanism for risk mitigation
THE LABEL IS THE LAW

4. Office of Pesticide Programs (OPP)
Mission:
To protect human health and the environment from unreasonable adverse effects resulting from the use of pesticides and to assure that there is a reasonable certainty of no harm from pesticides in the diet of all Americans, especially children.
2/22/2019

5. STATE LAW & RULES
Chapter , Florida Statutes
Rule 5E-2.031

6. FDACS Registration Reviews
Pesticides must be registered for sale in Florida
FDACS conducts reviews and risk assessments for special registrations
PREC: Multi-agency, technical reviews
Florida-specific concerns (e.g., water quality)
FDACS conducts risk assessments for pesticides appearing to cause unreasonable adverse effects despite proper use
Examples of effects: human health, non-target organisms, endangered species, water quality

7. Functions
REVIEW OF FEDERALLY APPROVED PESTICIDE LABELS BEFORE ACCEPTANCE FOR SALE AND DISTRIBUTION IN FLORIDA
REGISTRATION OPTIONS:
Register Without Conditions
Register With Conditions
Deny Registration

8. TYPES OF PESTICIDES CHEMICAL BIOPESTICIDE ANTIMICROBIAL
PEST CONTROL DEVICES
2/22/2019

9. Pesticide Registration Evaluation Committee (PREC)
PREC implements review responsibilities and obtains input from involved FDACS staff and affected state agencies
PREC is a technical coordination advisory committee that provides scientific feedback to FDACS

10. PREC - Membership
Bureau of Scientific Evaluation and Technical Assistance – Registration Review, Scientific Evaluation and Technical Assistance
Bureau of Licensing and Enforcement – Case Review Section
Bureau of Agricultural Environmental Laboratories
Bureau of Inspection and Incident Response
Division of Food Safety – Chemical Residue Laboratory
Florida Department of Environmental Protection
Florida Department of Health
Florida Fish and Wildlife Conservation
Commission

11. James Cooper, PhD, CPSS Environmental Administrator
Scientific Evaluation Section
Bureau of Scientific Evaluation and Technical Assistance (BSETA)
Division of Agricultural Environmental Services (AES)
Florida Department of Agriculture & Consumer Services (FDACS)
(850)
2/22/2019

12. Fate on Land
Physical Spray Drift
Volatilization, evaporation
Photodegradation in sunlight
Absorption by plant leaves/roots
Soil Metabolism-microbial degradation
Adsorbed to soil
Leaching to subsoil
Moving with runoff water
Moving with eroding soil
Capture by buffer areas
Fate in Surface Water Resources
Hydrolysis
Aqueous Photolysis
Plant uptake
Adsorption to sediments
Microbial metabolism (water/sediments)

13. Data Evaluation Needs Chemical properties: Extra Studies
Solubility
Aquatic field Dissipation
Vapor pressure
Mesocosm studies
Leaf metabolism
Leaf Wash-off
Laboratory/Field studies:
Kd subsoil
Hydrolysis (pH 5, 7 and 9)
Field Volatilization
Photolysis
Aerobic soil metabolism
Label Information
Anaerobic soil metabolism
Target site
Aerobic water metabolism
Application rate/Total load /year
Anaerobic water metabolism
Number of Applications
Terrestrial Field Dissipation
Application interval
Soil Adsorption Kd
Pre-harvest interval
Ground vs Aerial application
Buffer widths
Other label restrictions

14. Receiving Waters (directly or indirectly )
USEPA
Mississippi Farm Pond
Illinois Index Reservoir
Rice Paddy
FDACS
Wetland
North Florida Farm Pond
Central Florida lake
South Florida Canal

15. Environmental Fate Monitoring
Surface Water Models
Ground Water Modeling
Tier I
GENEEC
FIRST
Tier II
PRZM-EXAMS
PFAM
EXAMS
Tier 0.5 (RI)
Tier I
SCI-GROW
GUS
Tier II
Modified PRZM
PRZMGW

16. Practically Non-toxic
Water Label Target Toxicity
Herbicide Half-life Concentration Solubility Kd Fish LC Rat LD50
(days) (ppm) (ppm) ppm mg/kg BW
Bispyrac-sodium
11 to 42
0.045 73
0.6
100
Practically Non-toxic
>2600
Cafentrazone
3 to 9
Above Water
12 to 22 ND 2
Moderately Toxic
4,000
Copper
2 to 8 1
>730,000
----
<1
Highly Toxic
470
Diquat
1 to 7
0.37
700,000 15
245
230
Endothall
4 to 7 5
100,000
0.1
343
182
Flumioxazin
< 5
0.4
1.8 21
Slightly toxic
>5,000
Fluridone
20 to 82
0.15
1.2
2.7 14
>10,000
Glyphosate
12,000
>300
120
>5,600
Na-carbonate
peroxyhydrate
< 1
10.2
150,000
low 71
1,000
Imazamox
7 to 14
0.5
626
0.05
122
Imazapyr 3
11,000 82
Penoxsulam 25
4.9
103
Triclopyr 9
2.5
>400,000
0.2
148
730
Slightly Toxic
2,4-D
15 to 20
4.0
569
263
>1000