1. Volume 23, Issue 3, Pages 909-917 (April 2018)
A Gene Constellation in Avian Influenza A (H7N9) Viruses May Have Facilitated the Fifth Wave Outbreak in China 
Wenfei Zhu, Jie Dong, Ye Zhang, Lei Yang, Xiyan Li, Tao Chen, Xiang Zhao, Hejiang Wei, Hong Bo, Xiaoxu Zeng, Weijuan Huang, Zi Li, Jing Tang, Jianfang Zhou, Rongbao Gao, Li Xin, Jing Yang, Shumei Zou, Wenbing Chen, Jia Liu, Yuelong Shu, Dayan Wang 
Cell Reports 
Volume 23, Issue 3, Pages (April 2018)
DOI: /j.celrep
Copyright © 2018 The Author(s) Terms and Conditions

2. Cell Reports 2018 23, 909-917DOI: (10.1016/j.celrep.2018.03.081)
Copyright © 2018 The Author(s) Terms and Conditions

3. Figure 1
Phylogenetic Analysis and Geographic Disseminations of the HA and NA Genes of Influenza A (H7N9) Viruses
(A and B) In phylogenetic trees of HA (A) and NA (B) genes, all influenza A (H7N9) viruses can be geographically classified into two main lineages: the Yangtze River Delta lineage and the Pearl River Delta lineage. The branches in light blue, dark blue, purple, orange, and green represent viruses isolated in waves I, II, III, IV, and V, respectively. Substitutions shown above the branches indicate common mutations that occurred in the corresponding subclades.
(C and D) The numbers of viruses of different HA or NA gene lineages of influenza A (H7N9) viruses are shown (C). The number of isolated viruses in each of the HA and NA lineages is listed in the left column. Viruses were classified as belonging to the HA or NA lineages based on the phylogenetic analysis described in (A) and (B); the lineages included W5-1/W5-1a, W5-1b, W5-2, HPAI, PRDL (the Pearl River Delta lineage), Minor 1, and Minor 2. Geographic disseminations (D) of different lineage viruses based on HA genes are also indicated.
Cell Reports  , DOI: ( /j.celrep )
Copyright © 2018 The Author(s) Terms and Conditions

4. Figure 2
Evolution of the PB2 and NP Genes of Influenza A (H7N9) Viruses
(A and B) The branches in light blue, dark blue, purple, orange and green represent viruses isolated in waves I, II, III, IV, and V, respectively, for PB2 (A) and NP (B). Colors in the right panels indicate the H9N2 viruses isolated during waves III, IV, and V. Different subclades were nominated as previously described (Wang et al., 2016).
Cell Reports  , DOI: ( /j.celrep )
Copyright © 2018 The Author(s) Terms and Conditions

5. Figure 3
Development, Prevalence, and Diversity of Influenza A (H7N9) Viruses during the Five Outbreak Waves
(A) The development of influenza A (H7N9) genotypes from the first wave to the fifth wave. The gray blocks give the number of influenza A (H7N9) human infection cases per week. The 15 predominant genotypes (JS6455, ZJ11, AnH33225, FJ2, AnH9188, GD429, GD10, GD2, GD1, AnH1887, JS18828, JS537, JS1, SH7, and AnH1) are listed on the right. All transient genotypes are placed on the bottom line. Circles with different colors represent the corresponding genotypes of H7N9 viruses and their time of isolation. An increase in the size of circles is associated with an increase in the number of viruses of a particular genotype.
(B) The numbers of influenza A (H7N9) viruses isolated from humans or avian species are indicated by the purple and blue bars, respectively. The percentages of each predominant genotype, i.e., AnH1, JS537, JS537, JS18828, and ZJ11, in waves I, II, III, IV, and V, respectively, are plotted in blue (human isolated virus), orange (avian isolated virus), and green (both human and avian isolated virus) lines.
(C) Dynamic genotype diversity of the human isolated virus, avian isolated virus, and both, is indicated in blue, orange, and green lines, respectively.
Cell Reports  , DOI: ( /j.celrep )
Copyright © 2018 The Author(s) Terms and Conditions

6. Figure 4 Prevalence of a Specific Gene Constellation in Wave V
All the 435 H7N9 viruses isolated during wave V were used for gene constellation screening. The constellations uncovered here included a combination of 18 substitutions that are listed on the left. Substitutions that did or did not occur in the viruses are highlighted in steel blue or turquoise, respectively. Numbers in the boxes at the bottom indicate the quantity of genotype ZJ11 viruses (both in steel blue and turquoise) and other genotype viruses.
Cell Reports  , DOI: ( /j.celrep )
Copyright © 2018 The Author(s) Terms and Conditions