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Daniel L Miller, MD, Andrew M Roberts, PhD 

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Presentation on theme: "Daniel L Miller, MD, Andrew M Roberts, PhD "— Presentation transcript:

1 Pulmonary artery occlusion and reperfusion causes microvascular constriction in the rabbit lung 
Daniel L Miller, MD, Andrew M Roberts, PhD  The Annals of Thoracic Surgery  Volume 67, Issue 2, Pages (February 1999) DOI: /S (99)

2 Fig 1 Surgical preparation. Schematic drawing of instrumentation using a sternotomy approach. (P.A. = pulmonary artery; L.A. = left atrium). The Annals of Thoracic Surgery  , DOI: ( /S (99) )

3 Fig 2 Intravital video microscope. Drawing of the triocular microscope using incident illumination. The objective lens (L10 iris) was attached to a glass dipping cone. A color video camera was attached to the microscope to transmit images to a color monitor and then stored on videotape. Final magnification of the microscope was 550×. The Annals of Thoracic Surgery  , DOI: ( /S (99) )

4 Fig 3 Subpleural arteriole during baseline conditions. Normal caliber of vessel is visible as well as normal alveolar perfusion. The Annals of Thoracic Surgery  , DOI: ( /S (99) )

5 Fig 4 Subpleural arteriole during ischemia. There is no evidence of arteriolar blood flow, and scattered alveoli are pale secondary to ischemia. The Annals of Thoracic Surgery  , DOI: ( /S (99) )

6 Fig 5 Subpleural arteriole during early (30-minute) reperfusion. Significant vasoconstriction is evident as well as minimal perfusion of the associated alveolar walls. The Annals of Thoracic Surgery  , DOI: ( /S (99) )

7 Fig 6 Subpleural arteriole during late (60-minute) reperfusion. Arteriole diameters are near baseline dimensions; however, significant edema is present in arteriolar walls. The lung parenchyma appears to be injured, inflamed, and edematous. The Annals of Thoracic Surgery  , DOI: ( /S (99) )

8 Fig 7 Hemodynamic tracing of a representative animal taken at (A) baseline, (B) 10 minutes of reperfusion, (C) 30 minutes of reperfusion, and (D) 60 minutes of reperfusion. Microvascular observations were made during the periods when tracheal pressure was held constant (black dots). (PT = tracheal pressure; PPA = pulmonary artery pressure; QPA = pulmonary blood flow; PLA = left atrial pressure; ABP = systemic arterial blood pressure; HR = heart rate). The Annals of Thoracic Surgery  , DOI: ( /S (99) )

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