1. Human organism adaptation strategies to geomagnetic storms S. l. Zaguskin 1, A.K. Krylov 2, Y.V. Gurov 1, S.S. Zaguskina 1 1 Southern Federal University, Institute of physics, Rostov-on-Don, Russia, zaguskin@gmail.com, +79185144967 2 The establishment of the Russian Academy of Sciences, Institute of psychology of RAS, Moscow, Russia, neuru@mail.ru

2. Galactic radiation Solar activityMoon Magnetosphere, ozonosfera, atmosphere, hydrosphere, lithosphere PHYSICO-CHEMICAL EFFECTS ON THE BIOSPHERE Sol-gel transitions Man Body tissue Cell Society Biological connection, memory, traces processes Biorhythms: genetically anchored, homeostatic, exogenous

3. RHYTHMS OF SOLL-GEL TRANSITIONS IN A CELL AS ACCEPTORS AND RECEPTORS OF OUTSIDE IMPACTS Gel Sol Са i Primary/initial acceptors Receptors of cell membrane CN Н2ОН2О 1О21О2 Pm МPМP Са depot Function Biosynthesis Blood flow t°C, рН, Р оsм Physical impacts Chemical impacts Energy exchange of a cell Direct functional links, Feed back links, Energetic links ?

4. Interferometry of Stellar cluster «Snowflake» and differential interferometry of living neuron. Registration of rhythms sol-gel structures ?

5. Isolated neuron temporary connection output after increasing its energy metabolism 1- Neuron's activity during the action of laser exposure (dashed mark) and mechanical stimuli (solid mark) 2- combined impact 3- responses on the electric irritation and trace oscillations after elimination of the mechanical effects 4-neuron activation responses under electrical impact 1 2 3 4

6. Circahoral (20 min-2h) 5-min 1 - min 30 sec. 1-5s. (pulse, breath ) 7-13 Hz tremor, α-rhythm of brain 100 Hz-10kHz Biological rhythms Cosmic and geophysical rhythms B.M. Vladimirsky, 1980 It is likely that many of our problems.. are caused by contradiction between our internal time and the and the magnitude of external time in the world around us. I. Prigogine 1984

7. Evolutionary integration levels of biosystems Main levels: Biosphere, Biocenoses, Organisms, Cells, BSRC- biosynthetical self reduplicating cycles of sol-gel structures Biosphere Physical-Space Level (above Biosphere) Biocenoses Organisms Cells BSRC genes, viruses Physical-Chemical Level (pre-biological) CCH CCD Families,flock FSDO Ansambles FSO FSHB FSDB HMC DMC ТISSUES ORGANS Populations Consortii BIOMES ZONES m1m1 l1l1 k1k1 w1w1 v1v1 u1u1 y1y1 z1z1 x2x2 x1x1 u0u0 v0v0 w0w0 p1p1 r0r0 s0s0 r0r0 r1r1 s1s1 p2p2 r2r2 r3r3 r4r4 s4s4 s2s2 s3s3 z2z2 z3z3 z4z4 x3x3 x4x4 x5x5 y4y4 y3y3 y2y2 p5?p5? p4p4 p3p3 u3u3 u4u4 u2u2 u5u5 k2k2 k3k3 k4k4 k5?k5? l2l2 l3l3 l4l4 m2m2 m3m3 m4m4 v4v4 v3v3 v2v2 w2w2 w3w3 w4w4 z0z0 Intermediate Functional Levels: FSDB-functional systems of different types of biocenoses, FSHB-functional systems of homogenous types of biocenoses, FSO – functional systems of organism, CCD – cell compart- ments of different types, CCH - homogenous cell compartments. Intermediate Structural Levels: DMC-cell microstructures of different types, HМC –homogenous cell microstructures. Energy flows upon: x,y,z- functional & p,r,s-structural changes, u,v.w – parametrical regulation of function, k,l,m – parametrical regulation of structure.

9. Universal energy criterion of biological processes direction adaptation statusdisadaptation status 1 adaptation strategy ( ΔU N+1 <0) : Energy costs for external functional X N+1 and structural P N+1 processes are reduced less compared to internal regulatory Z N +S N processes. 2 adaptation strategy ( ΔU N+1 >0): Energy costs for external functional X N+1 and structural P N+1 processes is increasing more than on internal regulatory Z N +S N processes.

10. Energetic dependence of neuron irritability, and plastic fixation of its adaptation А Neuron activity pulse frequency records at irritation with the period of 5 minutes. Process of quick decrease of irritability since the beginning of irritation, and quick trigger recovery of irritability after 90 minutes is clearly seen. B Living ultraviolet cyto-spectre-photometry of neuron. Absorption oscillations with wave length equal to 265 nm at different points of neurons body. Primary increase of absorption (increase of РНП concentration) at points above nucleus as well as step-by-step phase synchronization of absorption oscillations at other parts of a cell following towards neuraxon are clearly seen. А B

11. 2 hour a maximum during ischemia a maximum during ischemia 1 hour a maximum during ischemia Increased periods and amplitude of rhythms of R-R intervals redundancy ( R=1Eexp/Emax) per 1, 2 hour and a maximum during ischemia Increased periods and amplitude of rhythms of R-R intervals redundancy ( R=1Eexp/Emax) per 1, 2 hour and a maximum during ischemia pulse breathing

12. Analysis of ECG R-R records with symbolic dynamic approach. Groups of people: young healthy (Y, black dots), eldery healthy (E gray dots), long-term atrial fibrillation (L, blue dots) and congestive heart failure (C red dots)

13. с – scope of 44 patients with congestive heart failure, l – is the area of 84 patients with atrial fibrillation, y – scope of 10 young healthy people, e – area of 54 older healthy people. k1 – a patient number 1, k2 – a patient number 2. Symbolic dynamics of R-R intervals k2k2 k1k1

14. Nerve cell of mechanical receptor of river crab. Registration of electrical activity, oxygen consumption, mitochondria aggregation, biosynthesis of protein and of other structural and chemical rhythms 70 мкм Camera upon microscope desk З- fixers З З З рО 2 electrode ganglion body of neuron muscles axon nerve

15. Increase of rhythms amplitude of sol-gel transitions under laser irradiation and stimulation of energy potential of a cell А - microfilm densitography method В - mitochondria aggregations С - increase of amplitude of mitochondria aggreg.- disaggreg.- oscillations (optical density 1-2), and sol level related to gel (liquid-faction of cytoplasm) while cell energetic has been stimulated with the help of natrium succinate (or laser) С А В sond 1 2 В A

16. Interferometry of living neuron with complete doubling of image. Registration of rhythms of protein content (dry weight) of non-disturbed cell and during physical impacts Photoelectrical method: Ф 0 -Ф 1 =А{cos 2 φ-Lcos 2 (φ-Δ/2)}+M Photographic method: (S 0 -S 1 )/γ=lg{cos 2 φ/Lcos 2 (φ-Δ/2)}-M

17. Synchronous oscillations of energetic exchange and biosynthesis in a cell About circahoral rhythms (average period is about 30 min) of protein at different zones of a cell: Д – between dendrites & nucleus, Я –at nucleus zone, А – between nucleus and neuraxon hill for absorption at 265 nm. Tuning: Оptical density - 0,1, Time - 30 мin. Neuraxon Neuroaxon Nucleus Living interferometry of the same neuron at the phase of about one hour rhythm of protein contents decrease (left) and at the phase of its increase (right). Change of shift of light wave phase above neuron bodys nucleus is clearly seen at the level of two nucleolus, and there are no changes at the part of coming down neuraxon. А Я Д Д Я

18. Criteria of optimum of laser therapy parameters Parameters are optimal during biocontrol mode only. Factor analysis of Ес, Т, S, λ values is not correct because response reactions are non- additive. Bio resonance is possible only if multifrequency biorhythmically biosynchronization is achieved.

19. Dependence of +/- responding reaction upon starting state and phase of rhythm of energetics of cell, tissue, organ, organism Yang Yin Following Towards Phаse of decrease of blood congestion = destruction Phase of increase of blood congestion = increase of biosynthesis Energy supply swing

20. Ratio оf 1-2-3 depths of amplitude modulation of physio- therapy impact changes depending upon mode of pathology (hypoxia, arterial or venous hyperemia) and upon availability of disbalance of arterial and venous parts of capillary route 1.Тremor 7-13Hz 2. Pulse 3. Breathing Total signal (1,2,3) of biocontrol systole diastole breath in breath out

21. «RIKTA-05» is the device for bio-controlled lasermagnet chronotherapy Chronodiagnostic and patients status control during chronotherapy session with bio control using pulse frequency (PF) to breathing frequency(BF) ratio. Normal: 3<PF/BF <5. Modes 1-4: different ratios of modulation depths due to pulse, breathing, tremor signals. Accounting for velocity of pulse wave and place of pathology, delay for pulse signal is introduced. During impact upon myocardium projection reverse of pulse signals sign is switched on. Pulses sensor Breath sensor Display: PF, BF, PF/BF, Bio-timer, modes 1-4 Теrminal: 8 red, 1 IR laser, magnet

22. Summary 1.Developed software and hardware-based medical diagnostic device «Kvant-bio». It contains a pulse, breathing and differential signal input block, thermometry of these sensors in the computer and display the signals on biofeedback matrix laser diodes with power via an adapter from the network. Сhronodiagnostic of human organism state and forecasting its adverse reactions to geomagnetic storms and weather anomalies by using special algorithms for symvolic dynamics of rhythms pulse, breathing and their relationships. Explores the rhythms of vegetation status, of cellular immunity, thermal gradients and thermal asymmetry. To resolve these desynchronosis and their prevention is used in the computer version of the respiratory gymnastics and biocontrol on respiration and pulse sensors with laser therapy. 2. Chronodiagnostic methods allow you to detect when a disagreement of biorhythms within the organism and with the rhythms of the external environment, the forecast adverse reaction of the organism to the geomagnetic storms and weather anomalies. 3. Biocontrolled chronophysiotherapy eliminates desynchronosis, resolves to normalize vegetative status, cell-mediated immunity, the spectrum of blood microcirculation rhythms in the pathology and prevention of adverse reactions of the human body for geomagnetic storms and weather anomalies.