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Nat. Rev. Rheumatol. doi: /nrrheum

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Presentation on theme: "Nat. Rev. Rheumatol. doi: /nrrheum"— Presentation transcript:

1 Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.219
Figure 2 Model of loading-induced TGFβ signalling in articular cartilage Figure 2 | Model of loading-induced TGFβ signalling in articular cartilage. Compressive loading results in the short-term release of active transforming growth factor-β (TGFβ) from latent TGFβ stored in the matrix. Active TGF1 binds to chondrocyte TGFβ receptors. Non-receptor-bound TGFβ becomes quickly unavailable owing to matrix binding. Binding of active TGFβ to activin receptor-like kinase 5 (ALK5) stimulates the expression of latent TGFβ1 and ALK5 while downregulating the expression of ALK1. Activation of this system blocks chondrocyte hypertrophy (Col10a1 expression). van der Kraan, P. M. (2017) The changing role of TGFβ in healthy, ageing and osteoarthritic joints Nat. Rev. Rheumatol. doi: /nrrheum

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