1. Cushing’s Syndrome(Disease)
in Dogs

2. WHAT IS IT? Hyperadrenocorticism Hyper- overactive/high
Adreno- adrenal gland
Corticism- refers to adrenal cortex
Cortisol- stress response
Too much weakens immune system

4. DON’T GET IT CONFUSED WITH ADDISON’S DISEASE
Hypoadrenocorticism
“Cushing’s is crushing”

5. CAUSES Pituitary Gland Tumor Most common: 80-90% Benign or Malignant
Macroadenomas >1cm
Microadenomas < 1cm

6. CAUSES Adrenal Gland Tumor Also Iatrogenic Cushing’s Disease
About 10-20%
Adenoma vs. Carcinoma
Also Iatrogenic Cushing’s Disease

7. EFFECTS ON BODY
Liver
Increases glucose production and release> Increases Insulin secretion
Muscles
Increases catabolic activity
Bones
Decreases osteoblast function
Increases osteoclast function
Kidneys
Increases glomerular blood flow and filtration rate
Hypertension

9. SYMPTOMS

10. TREATMENTS Pituitary Tumor Drugs Adrenal Tumor Surgery
Trilosane (Vetoryl)
Stops cortisol production
Mitotane (Lysodren)
Chemotherapy drug
Destroys layers of adrenal cortex
Adrenal Tumor
Surgery
Drugs before surgery to shrink tumor