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Christopher D. Owens, MD, MSc, Nicole Wake, BS, RVT, Michael S

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Presentation on theme: "Christopher D. Owens, MD, MSc, Nicole Wake, BS, RVT, Michael S"— Presentation transcript:

1 In vivo human lower extremity saphenous vein bypass grafts manifest flow mediated vasodilation 
Christopher D. Owens, MD, MSc, Nicole Wake, BS, RVT, Michael S. Conte, MD, Marie Gerhard-Herman, MD, Joshua A. Beckman, MD  Journal of Vascular Surgery  Volume 50, Issue 5, Pages (November 2009) DOI: /j.jvs Copyright © 2009 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Schematic of lower extremity cuff-induced ischemia technique. a, The superficial femoral artery is occluded and a saphenous vein bypass is shown. The cuff is placed distal to the distal anastomosis and inflated to suprasystolic pressures. b, Doppler spectral waveform of the vein graft demonstrating baseline, and (c) hyperemic flow patterns. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2009 Society for Vascular Surgery Terms and Conditions

3 Fig 2 a, Volumetric flow through human saphenous vein grafts (SVG) under basal and hyperemic conditions and pre and post 0.4 mg sublingual nitroglycerin. b, Endothelium-dependent and -independent vasodilatation in human saphenous vein bypass grafts. Baseline reflects baseline vein graft diameter. c, Flow mediated dilatation (FMD) and nitroglycerin mediated dilatation (NMD) in human SVGs. RH, Reactive hyperemia; NTG, nitroglycerin. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2009 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Regression analysis demonstrating a significant positive correlation between brachial artery and vein graft flow mediated dilation once normalized to reactive hyperemia (RH) flow stimulus, r = 0.64, P = FMD, Flow mediated dilatation. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2009 Society for Vascular Surgery Terms and Conditions

5 Fig 4 The contribution of nitric oxide (NO) to brachial artery and vein graft flow mediated dilatation (FMD) was examined by systemically infusing L-NGmonomethyl arginine (L-NMMA). Although NO contributes to brachial artery FMD in atherosclerotic patients, P = .05, (a) NO is likely the primary mediator of vein graft FMD, P = (b). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2009 Society for Vascular Surgery Terms and Conditions

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