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Tim Willinger, Richard A. Flavell  Cell Stem Cell 

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Presentation on theme: "Tim Willinger, Richard A. Flavell  Cell Stem Cell "— Presentation transcript:

1 ESCaping Rejection: A Step Forward for Embryonic-Stem-Cell-Based Regenerative Medicine 
Tim Willinger, Richard A. Flavell  Cell Stem Cell  Volume 14, Issue 1, Pages 3-4 (January 2014) DOI: /j.stem Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Protection of CTLA4-Ig/PD-L1 Knockin hESCs from Immune Rejection Parental hECS are rejected by human T cells in mice with a reconstituted human immune system (top). In contrast, hESC that constitutively express CTLA4-Ig and PD-L1, and differentiated cells derived from these engineered hESCs, escape rejection by creating a local immunosuppressive environment (bottom). Cell Stem Cell  , 3-4DOI: ( /j.stem ) Copyright © 2014 Elsevier Inc. Terms and Conditions


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