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H31m1-PDL1 cells form progressively growing tumors in WT mice.

Published byUrša Ninković Modified over 5 years ago

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Presentation on theme: "H31m1-PDL1 cells form progressively growing tumors in WT mice."— Presentation transcript:

1 H31m1-PDL1 cells form progressively growing tumors in WT mice.
H31m1-PDL1 cells form progressively growing tumors in WT mice. A, Left: In vivo tumor growth of unedited H31m1 MCA sarcoma cells in WT mice. Mice bearing H31m1 cells were left untreated. Data are shown by mean ± SEM from at least two independent experiments (n = 5). Right: Numbers of PD-L1 molecules on tumor (CD45−) and immune cells (CD45+) in vivo. Data are shown by mean ± SEM from two independent experiments (n = 4). B,In vitro PD-L1 expression on cells treated with or without IFNγ (100 ng/mL) for 24 hours. Data are shown from at least two independent experiments. Red, unstained; blue, isotype control; orange, anti–PD-L1. C,In vivo tumor growth of H31m1 parental and H31m1-PDL1 tumor cells in WT mice. Tumor cells (10 × 106) were injected on day 0. Data shown in this figure are representative of at least two independent experiments (n = 20). Takuro Noguchi et al. Cancer Immunol Res 2017;5: ©2017 by American Association for Cancer Research

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