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Biology
Biology
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2. 12-3 RNA and Protein Synthesis
Ch 12 RNA and Protein Synthesis
EQ; How does protein synthesis occur?
12-3 RNA and Protein Synthesis
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3. 12–3 RNA and Protein Synthesis
Genes are coded DNA instructions that control the production of proteins.
Genetic messages can be decoded by copying part of the nucleotide sequence from DNA into RNA.
RNA contains coded information for making proteins.
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The Structure of RNA
The Structure of RNA
There are three main differences between RNA and DNA:
The sugar in RNA is ribose instead of deoxyribose.
RNA is generally single-stranded.
RNA contains uracil in place of thymine.
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Types of RNA
Types of RNA
There are three main types of RNA:
messenger RNA
ribosomal RNA
transfer RNA
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Types of RNA
The three main types of RNA are messenger RNA, ribosomal RNA, and transfer RNA.
Messenger RNA (mRNA) carries copies of instructions for assembling amino acids into proteins.
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Types of RNA
Ribosome
Ribosomal RNA
The three main types of RNA are messenger RNA, ribosomal RNA, and transfer RNA. Ribosomal RNA is combined with proteins to form ribosomes.
Ribosomes are made up of proteins and ribosomal RNA (rRNA).
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Types of RNA
Amino acid
The three main types of RNA are messenger RNA, ribosomal RNA, and transfer RNA.
Transfer RNA
During protein construction, transfer RNA (tRNA) transfers each amino acid to the ribosome.
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9. Protein Synthesis DNA molecule DNA strand (template) 3¢ 5¢
TRANSCRIPTION
mRNA 5¢ 3¢
Codon
TRANSLATION
Protein
Amino acid

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Transcription
Transcription
DNA is copied in the form of RNA
This first process is called transcription.
The process begins at a section of DNA called a promoter.
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Transcription
RNA
RNA polymerase
DNA
During transcription, RNA polymerase uses one strand of DNA as a template to assemble nucleotides into a strand of RNA.
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The Genetic Code
The Genetic Code
The genetic code is the “language” of mRNA instructions.
The code is written using four “letters” (the bases: A, U, C, and G).
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The Genetic Code
A codon consists of three consecutive nucleotides on mRNA that specify a particular amino acid.
A codon is a group of three nucleotides on messenger RNA that specify a particular amino acid.
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The Genetic Code
The genetic code shows the amino acid to which each of the 64 possible codons corresponds. To decode a codon, start at the middle of the circle and move outward.
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Translation
Translation
Translation is the decoding of an mRNA message into a polypeptide chain (protein).
Translation takes place on ribosomes.
During translation, the cell uses information from messenger RNA to produce proteins.
Nucleus
mRNA
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Translation
The ribosome binds new tRNA molecules and amino acids as it moves along the mRNA.
Lysine
Phenylalanine
tRNA
Methionine
Ribosome
During translation, or protein synthesis, the cell uses information from messenger RNA to produce proteins. The cell uses all three main forms of RNA during this process.
mRNA
Start codon
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Translation
Protein Synthesis
Lysine
tRNA
During translation, or protein synthesis, the cell uses information from messenger RNA to produce proteins. The cell uses all three main forms of RNA during this process.
mRNA
Translation direction
Ribosome
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Translation
The process continues until the ribosome reaches a stop codon.
Polypeptide
Ribosome
tRNA
During translation, or protein synthesis, the cell uses information from messenger RNA to produce proteins. The cell uses all three main forms of RNA during this process.
mRNA
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19. Amino acids within a polypeptide
Genes and Proteins
Codon
Codon
Codon
DNA
mRNA
Protein
Single strand of DNA
Codon
Codon
Codon
mRNA
This diagram illustrates how information for specifying the traits of an organism is carried in DNA. The sequence of bases in DNA is used as a template for mRNA. The codons of mRNA specify the sequence of amino acids in a protein, and proteins play a key role in producing an organism’s traits.
Alanine
Arginine
Leucine
Amino acids within a polypeptide
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What causes a mutation to occur?
Mutations are changes in the genetic material.
12-4 Mutations
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Kinds of Mutations
Mutations that produce changes in a single gene are known as gene mutations.
Mutations that produce changes in whole chromosomes are known as chromosomal mutations.
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Kinds of Mutations
Gene Mutations 
Gene mutations involving a change in one or a few nucleotides are known as point mutations because they occur at a single point in the DNA sequence.
Point mutations include substitutions, insertions, and deletions.
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