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Randomized trial of the effect of drug presentation on asthma outcomes: The American Lung Association Asthma Clinical Research Centers  Robert A. Wise,

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Presentation on theme: "Randomized trial of the effect of drug presentation on asthma outcomes: The American Lung Association Asthma Clinical Research Centers  Robert A. Wise,"— Presentation transcript:

1 Randomized trial of the effect of drug presentation on asthma outcomes: The American Lung Association Asthma Clinical Research Centers  Robert A. Wise, MD, Susan J. Bartlett, PhD, Ellen D. Brown, MS, Mario Castro, MD, Rubin Cohen, MD, Janet T. Holbrook, PhD, Charles G. Irvin, PhD, Cynthia S. Rand, PhD, Marianna M. Sockrider, MD, Elizabeth A. Sugar, PhD  Journal of Allergy and Clinical Immunology  Volume 124, Issue 3, Pages e8 (September 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Enrollment, randomization, and follow-up of study participants. All patients for whom follow-up data were available were included in the analysis, regardless of whether they discontinued treatment. Participants assigned to the ”Regular“ presentation received a neutral message about drug efficacy. Those assigned to Usual Care received no drug treatment and were only given asthma education brochures. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Factorial treatment combinations that were randomly assigned in order to determine the main and interactive effects of drug assignment and treatment presentation. A fifth group received usual care. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 This figure illustrates the study schema
This figure illustrates the study schema. Asthma diaries and daily peak expiratory flows (PEF) were collected for two weeks prior to randomization and during four weeks of treatment. Asthma symptoms and lung function were assessed at baseline and after two weeks and four weeks of treatment. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 This figure illustrates one of the panels in the computer presentation including messages such as branding (Singulair), Authority (FDA, Merck) and Peer identification (attractive healthy adult of indeterminate age and race). Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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