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Amin S. Herati, M. D. , Boryana H. Zhelyazkova, B. A. , Peter R

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Presentation on theme: "Amin S. Herati, M. D. , Boryana H. Zhelyazkova, B. A. , Peter R"— Presentation transcript:

1 Age-related alterations in the genetics and genomics of the male germ line 
Amin S. Herati, M.D., Boryana H. Zhelyazkova, B.A., Peter R. Butler, B.A., Dolores J. Lamb, Ph.D.  Fertility and Sterility  Volume 107, Issue 2, Pages (February 2017) DOI: /j.fertnstert Copyright © Terms and Conditions

2 Figure 1 Reactive oxygen species generated from the mitochondrial electron transport chain (black arrow) damage DNA and mitochondrial DNA and disrupt telomerase activity, causing germ cell senescence. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © Terms and Conditions

3 Figure 2 Development of genomic instability with aging.
Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © Terms and Conditions


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