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Coenzyme Q–dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging  Assaf Ben-Meir, M.D., Shlomi Yahalomi, M.D., Brit.

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Presentation on theme: "Coenzyme Q–dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging  Assaf Ben-Meir, M.D., Shlomi Yahalomi, M.D., Brit."— Presentation transcript:

1 Coenzyme Q–dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging  Assaf Ben-Meir, M.D., Shlomi Yahalomi, M.D., Brit Moshe, B.Sc., Yoel Shufaro, M.D., Ph.D., Benjamin Reubinoff, M.D., Ph.D., Ann Saada, Ph.D.  Fertility and Sterility  Volume 104, Issue 3, Pages (September 2015) DOI: /j.fertnstert Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 The correlation between mitochondrial protein amount and complex II + III activity with and without coenzyme Q1. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Enzymatic activity of mitochondrial complexes in granulosa cells from younger and older patients. II + III = complexes II + III; II + III + Q = complexes II + III activity with coenzyme Q1 supplementation. CS = citrate synthase; SDH = succinate dehydrogenase. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Fold change in complexes II + III activity with and without coenzyme Q1 supplementation (II + III + Q/II + III) in granulosa cells from younger and older patients. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions


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