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Multiple Lung Adenocarcinomas Associated With Von Hippel-Lindau Disease  Koei Ikeda, MD, PhD, Hironobu Osumi, MD, Kentaro Matsuishi, MD, Eri Matsubara,

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Presentation on theme: "Multiple Lung Adenocarcinomas Associated With Von Hippel-Lindau Disease  Koei Ikeda, MD, PhD, Hironobu Osumi, MD, Kentaro Matsuishi, MD, Eri Matsubara,"— Presentation transcript:

1 Multiple Lung Adenocarcinomas Associated With Von Hippel-Lindau Disease 
Koei Ikeda, MD, PhD, Hironobu Osumi, MD, Kentaro Matsuishi, MD, Eri Matsubara, MD, Kousuke Fujino, MD, Hidekatsu Shibata, MD, PhD, Kentaro Yoshimoto, MD, PhD, Kenji Shiraishi, MD, PhD, Takeshi Mori, MD, PhD, Makoto Suzuki, MD, PhD  The Annals of Thoracic Surgery  Volume 98, Issue 4, Pages (October 2014) DOI: /j.athoracsur Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 The findings from (A–C) computed tomography scans and from (D, E, hematoxylin-eosin stain, magnification ×100) pathology examination of the resected specimens and (F, hematoxylin-eosin stain, magnification ×400) the needle biopsy specimen are shown. (A, D) Adenocarcinoma (arrow) in the right middle lobe. (B, E) Atypical adenomatous hyperplasia (arrow) in the left upper lobe. (C, F) Adenocarcinoma (arrow) in the left upper lobe. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 The DNA sequencing electropherograms display the nucleotide sequence of the DNA from the peripheral blood mononuclear cells of (A) the patient and (B) a control. (A) The tracings from the patient show a C to T mutation, which indicates that the patient carries a germline mutation in codon 65 of exon 1 of the VHL gene. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Relative quantification of the copy number assay of the VHL gene. Loss of heterozygosity was detected in the DNA of the tumor tissue specimen. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

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