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BRCA1 Gene Mutation in Thymic Malignant Melanoma

Published byJeremy Flynn Modified over 6 years ago

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Presentation on theme: "BRCA1 Gene Mutation in Thymic Malignant Melanoma"— Presentation transcript:

1 BRCA1 Gene Mutation in Thymic Malignant Melanoma
Eun Jue Yi, MD, Jong Ho Park, MD, PhD, Hae Won Lee, MD, PhD, Soo Youn Cho, MD, PhD, Im Il Na, MD, Moon Chul Kang, MD  The Annals of Thoracic Surgery  Volume 96, Issue 2, Pages (August 2013) DOI: /j.athoracsur Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Chest computed tomography scan of a patient with thymic malignant melanoma shows a 2 × 3-cm anterior mediastinal mass (indicated by an arrow). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 In the gross appearance of the excised mass, a relatively demarcated, yellowish, and partly brown pigmented tumor is noted in the thymus (red circle). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Microscopic analysis of the thymus of a patient with malignant melanoma. (A) Hematoxylin and eosin staining of the thymic tissue reveals diffuse brown pigments (original magnification ×400). Photomicrographs show (B) S-100 and (C) human melanoma black-45 are highly expressed in tumor cells (left side), but not in normal thymic tissue (right upper; original magnification ×100). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 DNA sequence electropherograms of exon 24 of BRCA1 from a blood sample obtained from a patient with thymic malignant melanoma. The red circle indicates a BRCA1 mutation. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

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