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Hong Wei Chu, MDa, Monica Kraft, MDa, James E. Krause, PhDb, Michael D

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Presentation on theme: "Hong Wei Chu, MDa, Monica Kraft, MDa, James E. Krause, PhDb, Michael D"— Presentation transcript:

1 Substance P and its receptor neurokinin 1 expression in asthmatic airways 
Hong Wei Chu, MDa, Monica Kraft, MDa, James E. Krause, PhDb, Michael D. Rex, BSa, Richard J. Martin, MDa  Journal of Allergy and Clinical Immunology  Volume 106, Issue 4, Pages (October 2000) DOI: /mai Copyright © 2000 Mosby, Inc. Terms and Conditions

2 Fig. 1 Representative photomicrographs of immunostaining on endobronchial biopsy samples. Substance P (a) and neurokinin 1 (b) staining in a normal control subject. Substance P (c) and neurokinin 1 (d) staining in an asthmatic subject. The arrow in d indicates the neurokinin 1 staining on endothelial cells of a blood vessel in the submucosa. Asthmatic biopsy sections incubated with either substance P peptide preabsorbed substance P antibody (e) or neurokinin 1 peptide preabsorbed neurokinin 1 antibody (f) . Alcian-blue/periodic acid–Schiff staining for mucus in a normal control subject (g) and an asthmatic subject (h) . (Original magnification, 400×.) Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

3 Fig. 2 Comparisons of substance P and neurokinin 1 (NK1) expression in endobronchial biopsy samples between normal control subjects and asthmatic subjects. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

4 Fig. 3 A, Epithelial substance P and neurokinin 1 (NK1) expression in asthmatic subjects at baseline and after 6 weeks of clarithromycin treatment. B, Submucosal substance P and neurokinin 1 (NK1) expression in asthmatic subjects at baseline and after 6 weeks of clarithromycin treatment. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

5 Fig. 4 Comparisons of epithelial mucus production in endobronchial biopsy samples of normal control subjects and asthmatic subjects at baseline. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

6 Fig. 5 A, Correlation between epithelial substance P expression and epithelial mucus content. B, Correlation between epithelial mucus content and FEV1 percent predicted. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

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