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Duration of Dual Antiplatelet Therapy Post-ACS: Lessons from Clinical Trials.

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Presentation on theme: "Duration of Dual Antiplatelet Therapy Post-ACS: Lessons from Clinical Trials."— Presentation transcript:

1 Duration of Dual Antiplatelet Therapy Post-ACS: Lessons from Clinical Trials

2

3 Overview

4 Case Study

5 Acute Intervention

6 Current Medications

7 Physical Exam/Lab Findings

8 Subjective

9 Red Flags for Risk of Nonadherence?

10 Helpful Tips

11 Ubiquity of the Nonadherence Problem

12 Addressing Barriers With the Patient as Partner

13 DAPT Trial: Stent Thrombosis and MACCE

14 PEGASUS: HRs and Rates of the Primary Endpoint

15 Relative Risks for All-Cause Mortality in Good vs Poor Adherence to Major CV Medications

16 The Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies (SWEDEHEART)

17 Major Efficacy and Safety Endpoints in PLATO and SWEDEHEART

18 Case Study: 12-Month Visit

19 Factors Favoring Longer DAPT

20 Calculation of a DAPT Score

21 Multivariable Prediction Model and Derivation of the Score

22 Effect of Long (12- to 24-Month) vs Short (3- to 6-month) DAPT (ACS Subgroup)

23 New Paradigms

24 Clinical Decision Making Vision for the Future

25 Patient Engagement

26 Future of Medication Adherence

27 Concluding Remarks

28 Abbreviations

29 Abbreviations (cont)


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