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Triple vs Dual Antithrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease  Renato D. Lopes, MD, MHS, PhD, Meena Rao, MD,

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Presentation on theme: "Triple vs Dual Antithrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease  Renato D. Lopes, MD, MHS, PhD, Meena Rao, MD,"— Presentation transcript:

1 Triple vs Dual Antithrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease  Renato D. Lopes, MD, MHS, PhD, Meena Rao, MD, DaJuanicia N. Simon, MS, Laine Thomas, PhD, Jack Ansell, MD, Gregg C. Fonarow, MD, Bernard J. Gersh, MB, ChB, DPhil, Alan S. Go, MD, Elaine M. Hylek, MD, MPH, Peter Kowey, MD, Jonathan P. Piccini, MD, MHS, Daniel E. Singer, MD, Paul Chang, MD, Eric D. Peterson, MD, MPH, Kenneth W. Mahaffey, MD  The American Journal of Medicine  Volume 129, Issue 6, Pages e1 (June 2016) DOI: /j.amjmed Copyright © 2016 The Authors Terms and Conditions

2 Figure 1 Flow diagram of study population according to antithrombotic therapy. CAD = coronary artery disease; DAP = dual antithrombotic therapy with 2 antiplatelet agents; OAC + AA = dual antithrombotic therapy with an oral anticoagulant plus 1 antiplatelet agent. The American Journal of Medicine  , e1DOI: ( /j.amjmed ) Copyright © 2016 The Authors Terms and Conditions

3 Figure 2 Antithrombotic strategy by CHA2DS2-VASc score. DAP = dual antithrombotic therapy with 2 antiplatelet agents; OAC + AA = dual antithrombotic therapy with an oral anticoagulant plus 1 antiplatelet agent; TT = triple antithrombotic therapy (oral anticoagulation plus dual antiplatelet therapy). The American Journal of Medicine  , e1DOI: ( /j.amjmed ) Copyright © 2016 The Authors Terms and Conditions

4 Figure 3 Antithrombotic strategy by ATRIA bleeding score. ATRIA = Anticoagulation and Risk Factors in Atrial Fibrillation; DAP = dual antithrombotic therapy with 2 antiplatelet agents; OAC + AA = dual antithrombotic therapy with an oral anticoagulant plus 1 antiplatelet agent; TT = triple anti-throm-botic therapy (oral anticoagulation plus dual antiplatelet therapy). The American Journal of Medicine  , e1DOI: ( /j.amjmed ) Copyright © 2016 The Authors Terms and Conditions

5 Figure 4 1-year outcomes. CI = confidence interval; CNS = central nervous system; DAP = dual antithrombotic therapy with 2 antiplatelet agents; HR = hazard ratio; MI = myocardial infarction; OAC + AA = dual antithrombotic therapy with an oral anticoagulant plus 1 antiplatelet agent; TIA = transient ischemic attack; TT = triple antithrombotic therapy (oral anticoagulation plus dual antiplatelet therapy). The American Journal of Medicine  , e1DOI: ( /j.amjmed ) Copyright © 2016 The Authors Terms and Conditions

6 Figure 5 Cumulative incidence plot showing all-cause hospitalization at 1 year. DAP = dual antithrombotic therapy with 2 antiplatelet agents; OAC + AA = dual antithrombotic therapy with an oral anticoagulant plus 1 antiplatelet agent; TT = triple antithrombotic therapy (oral anticoagulation plus dual antiplatelet therapy). The American Journal of Medicine  , e1DOI: ( /j.amjmed ) Copyright © 2016 The Authors Terms and Conditions

7 Supplementary Figure Antithrombotic strategy by CHADS2 score. DAP = dual antithrombotic therapy with 2 antiplatelet agents; OAC + AA = dual antithrombotic therapy with an oral anticoagulant plus 1 antiplatelet agent; TT = triple anti-throm-botic therapy (oral anticoagulation plus dual antiplatelet therapy). The American Journal of Medicine  , e1DOI: ( /j.amjmed ) Copyright © 2016 The Authors Terms and Conditions


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