1. C1orf106 is an IBD susceptibility gene expressed primarily in gut-associated tissues and between epithelial cell junctions.
C1orf106 is an IBD susceptibility gene expressed primarily in gut-associated tissues and between epithelial cell junctions. (A) Selection of C1orf106 SNPs associated with IBD or celiac disease. Annotation indicates location of SNP relative to C1orf106. The celiac disease risk SNP rs has been mapped to a different gene (MROH3P) but is in high linkage disequilibrium with the IBD risk SNP rs (r2 = 0.8). (B) Mouse tissue transcripts of C1orf106 in the stomach, colon, and small intestine by quantitative PCR analysis. (C and D) C1ORF106 mRNA and protein expression of sorted populations from colon tissue from three subjects undergoing resection for diverticulitis. (E) Confocal immunofluorescence images from Caco2 cell monolayers immunostained with anti-C1ORF106, anti-occludin, and DAPI. Original magnification ×40. (F) C1orf106 transcript in IBD patient with indicated rs genotypes. *p < 0.05.
Paolo Manzanillo et al. ImmunoHorizons 2018;2:
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