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Poly-GR and poly-PR co-aggregate with ribosomal proteins in C9orf72 patients. Poly-GR and poly-PR co-aggregate with ribosomal proteins in C9orf72 patients.

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Presentation on theme: "Poly-GR and poly-PR co-aggregate with ribosomal proteins in C9orf72 patients. Poly-GR and poly-PR co-aggregate with ribosomal proteins in C9orf72 patients."— Presentation transcript:

1 Poly-GR and poly-PR co-aggregate with ribosomal proteins in C9orf72 patients.
Poly-GR and poly-PR co-aggregate with ribosomal proteins in C9orf72 patients. (A) Immunofluorescent stainings of components of the small (RPS6) and large (RPL19) ribosomal subunits in C9orf72 patient brains and controls. Additional ribosomal proteins are shown in Fig S4B. Note the enrichment of ribosomal proteins in poly-GR/PR inclusions. DAPI marks nuclei in blue. Single confocal planes were taken. Scale bar depicts 20 μm. (B) Quantitative analysis of co-localization of ribosomal proteins with poly-GR aggregates (n = 3 sections with 100 poly-GR aggregates counted each from C9orf72 cortex, mean ± SEM is shown). Hannelore Hartmann et al. LSA 2018;1:e © 2018 Hartmann et al.

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