1. Navigating Treatment Options in PAH

2. Program Goals

3. Case Study 1

4. Case Study 1 (cont)

5. Case Study 1 (cont)

6. Risk Stratification

7. Treatment Goals

8. SERAPHIN PAH Population

11. Combination Therapy Options for PAH

12. 1-Year Survival Estimates in the Subsequent Year by Change in REVEAL Score

13. Case Study 2 Initial Visit December 2015

14. Case Study 2 Test Results

15. Treatment Algorithm for PAH

16. Rationale for Combination Therapy

17. AMBITION Study Design

18. AMBITION Results

19. Concluding Comments

20. Abbreviations

21. Abbreviations (cont)

22. Abbreviations (cont)