Presentation is loading. Please wait.

Presentation is loading. Please wait.

Effects of high progesterone level on the day of human chorionic gonadotrophin administration in in vitro fertilization cycles on epigenetic modification.

Similar presentations


Presentation on theme: "Effects of high progesterone level on the day of human chorionic gonadotrophin administration in in vitro fertilization cycles on epigenetic modification."— Presentation transcript:

1 Effects of high progesterone level on the day of human chorionic gonadotrophin administration in in vitro fertilization cycles on epigenetic modification of endometrium in the peri-implantation period  Yujing Xiong, M.Phil., Jianzhang Wang, M.Phil., Liu Liu, M.D., Xiaoyan Chen, M.Phil., Hui Xu, Ph.D., Tin Chiu Li, M.D., Ph.D., Chi Chiu Wang, Ph.D., Songying Zhang, M.D., Ph.D.  Fertility and Sterility  Volume 108, Issue 2, Pages e1 (August 2017) DOI: /j.fertnstert Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Expression and comparison of (A–E) 5-mC in three compartments of endometrium from women with normal P level and high P level. The expression of 5-mC in the glandular epithelium of the high P group was significantly (P=.03) higher than that in the normal P group (E). The black arrow indicates positive staining. Scale bar = 50 μm. GE = glandular epithelia; LE = luminal epithelia; n.s. = not significant; SC = stromal cell. Values expressed are mean + SD. *P < .05. Fertility and Sterility  , e1DOI: ( /j.fertnstert ) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Expression and comparison of (A–E) H3K4me2/3, (F–J) H3K9me2, and (K–O) H3K27me3 in three compartments of endometrium from women with normal P level and high P level. The expression level of H3K4me2/3 in all three compartments was not significantly different between the two groups (C, D, and E). The expression of H3K9me2 in the luminal epithelium and glandular epithelium of the high P group was significantly (P=.02 and P=.001, respectively) higher than that in the normal P group (H and J). The expression of H3K27me3 in the stroma of the high P group was significantly (P=.02) higher than that in the normal P group (N). The black arrow indicates positive staining. Scale bar = 50 μm. GE = glandular epithelia; LE = luminal epithelia; SC = stromal cell. Values expressed are mean + SD. *P < .05. Fertility and Sterility  , e1DOI: ( /j.fertnstert ) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Expression and comparison of (A–E) H3K4ac and (F–J) H3K9ac in three compartments of endometrium from women with normal P level and high P level. The expression of H3K4ac in all three compartments was not significantly different between the two groups (C, D, and E). The expression of H3K9ac in the glandular epithelium of the high P group was significantly (P=.04) higher than that in the normal P group (J). Scale bar = 50 μm. GE = glandular epithelia; LE = luminal epithelia; n.s. = not significant; SC = stromal cell. Values expressed are mean + SD. *P < .05. Fertility and Sterility  , e1DOI: ( /j.fertnstert ) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions


Download ppt "Effects of high progesterone level on the day of human chorionic gonadotrophin administration in in vitro fertilization cycles on epigenetic modification."

Similar presentations


Ads by Google