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Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma  Takashi Kinoshita, MD, Adrian Baatjes, MSc,

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Presentation on theme: "Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma  Takashi Kinoshita, MD, Adrian Baatjes, MSc,"— Presentation transcript:

1 Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma  Takashi Kinoshita, MD, Adrian Baatjes, MSc, Steven G. Smith, PhD, Benny Dua, MSc, Richard Watson, BSc, Tomotaka Kawayama, MD, Mark Larche, PhD, Gail M. Gauvreau, PhD, Paul M. O’Byrne, MD, FRCPI  Journal of Allergy and Clinical Immunology  Volume 133, Issue 3, Pages (March 2014) DOI: /j.jaci Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Flow cytometric CD4+Foxp3+ Treg cell gating strategy and gating strategy for the determination of absolute numbers in sputum and peripheral blood. A, CD4+Foxp3+ Treg cell gating strategy (representative sputum sample): 1, CD3+ gate; 2, CD3+CD4+ gate; 3, CD4 versus Foxp3 isotype control; and 4, CD4 versus Foxp3. B, Flow cytometric gating for determination of absolute numbers: i, sputum; ii, peripheral blood. FSC, Forward scatter; SSC, side scatter. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Allergen-induced EARs and LARs.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Changes in CD4+ cell absolute numbers and percentages. A, Sputum absolute number. B, Sputum percentage. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Changes in CD4+Foxp3+ Treg cell absolute numbers and percentages. A, Sputum absolute number. B, Sputum percentage. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 Ratio of absolute Treg cell to CD4+ cell numbers in sputum of IERs versus DRs. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig 6 Correlation of change in sputum CD4+Foxp3+ Treg cell percentages (0-24 hours) versus LARs. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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