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Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage  Daniel Woo, Guido J. Falcone,

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Presentation on theme: "Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage  Daniel Woo, Guido J. Falcone,"— Presentation transcript:

1 Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage  Daniel Woo, Guido J. Falcone, William J. Devan, W. Mark Brown, Alessandro Biffi, Timothy D. Howard, Christopher D. Anderson, H. Bart Brouwers, Valerie Valant, Thomas W.K. Battey, Farid Radmanesh, Miriam R. Raffeld, Sylvia Baedorf-Kassis, Ranjan Deka, Jessica G. Woo, Lisa J. Martin, Mary Haverbusch, Charles J. Moomaw, Guangyun Sun, Joseph P. Broderick, Matthew L. Flaherty, Sharyl R. Martini, Dawn O. Kleindorfer, Brett Kissela, Mary E. Comeau, Jeremiasz M. Jagiella, Helena Schmidt, Paul Freudenberger, Alexander Pichler, Christian Enzinger, Björn M. Hansen, Bo Norrving, Jordi Jimenez-Conde, Eva Giralt-Steinhauer, Roberto Elosua, Elisa Cuadrado-Godia, Carolina Soriano, Jaume Roquer, Peter Kraft, Alison M. Ayres, Kristin Schwab, Jacob L. McCauley, Joanna Pera, Andrzej Urbanik, Natalia S. Rost, Joshua N. Goldstein, Anand Viswanathan, Eva-Maria Stögerer, David L. Tirschwell, Magdy Selim, Devin L. Brown, Scott L. Silliman, Bradford B. Worrall, James F. Meschia, Chelsea S. Kidwell, Joan Montaner, Israel Fernandez-Cadenas, Pilar Delgado, Rainer Malik, Martin Dichgans, Steven M. Greenberg, Peter M. Rothwell, Arne Lindgren, Agnieszka Slowik, Reinhold Schmidt, Carl D. Langefeld, Jonathan Rosand  The American Journal of Human Genetics  Volume 94, Issue 4, Pages (April 2014) DOI: /j.ajhg Copyright © 2014 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Genome-wide Association Study Results
Genome-wide association study results of autosomal SNPs: (A) all (lobar ICH and nonlobar ICH combined), (B) lobar ICH, and (C) nonlobar ICH. The plots show –log10-transformed p values for genotyped and imputed SNPs with respect to their physical positions. The threshold for association at genome-wide significance (p = 5 × 10−8) is shown by the upper dashed line, and the lower dashed line corresponds to p = 1 × 10−5. Landmark genes are indicated for loci that reached the threshold to pursue replication. The American Journal of Human Genetics  , DOI: ( /j.ajhg ) Copyright © 2014 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Meta-analysis Results
Forest plots describing effect estimates for participating studies, as well as for the replication effort. Pooled estimates for odds ratios and 95% confidence intervals were calculated by fixed effects, inverse variance weighting meta-analysis. (A) Association results for rs at chromosomal region 12q21.1 in lobar ICH. (B) Association results for rs at chromosomal region 1q22 in nonlobar ICH. Results correspond to effect estimates when testing the major allele to depict genetic variation associated with increased risk of ICH. The American Journal of Human Genetics  , DOI: ( /j.ajhg ) Copyright © 2014 The American Society of Human Genetics Terms and Conditions

4 Figure 3 Zoom Plots Regional association results.
(A) Chromosomal region 1q22 in nonlobar ICH. (B) Chromosomal region 12q21.1 in lobar ICH. The index-associated SNP is labeled with violet color. The American Journal of Human Genetics  , DOI: ( /j.ajhg ) Copyright © 2014 The American Society of Human Genetics Terms and Conditions


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