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Mobilized Peripheral Blood Stem Cells Compared with Bone Marrow as the Stem Cell Source for Unrelated Donor Allogeneic Transplantation with Reduced-Intensity.

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Presentation on theme: "Mobilized Peripheral Blood Stem Cells Compared with Bone Marrow as the Stem Cell Source for Unrelated Donor Allogeneic Transplantation with Reduced-Intensity."— Presentation transcript:

1 Mobilized Peripheral Blood Stem Cells Compared with Bone Marrow as the Stem Cell Source for Unrelated Donor Allogeneic Transplantation with Reduced-Intensity Conditioning in Patients with Acute Myeloid Leukemia in Complete Remission: An Analysis from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation  Arnon Nagler, Myriam Labopin, Avichai Shimoni, Dietger Niederwieser, Ghulam J. Mufti, Axel R. Zander, Renate Arnold, Hildegard Greinix, Jan J. Cornelissen, Graham H. Jackson, Charles Craddock, Donald W. Bunjes, Arnold Ganser, Nigel H. Russell, Slawomira Kyrcz-Krzemien, Vanderson Rocha, Mohamad Mohty  Biology of Blood and Marrow Transplantation  Volume 18, Issue 9, Pages (September 2012) DOI: /j.bbmt Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Probability of 2-year non-relapse mortality (NRM) after reduced-intensity conditioning (RIC) allogeneic stem cell transplant (alloSCT) with mobilized peripheral blood stem cell graft (PBSC; n = 508) versus bone marrow (BM) graft (n = 94; P Gray test = .004; P Cox = .015). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Probability of relapse after reduced-intensity conditioning (RIC) allogeneic stem cell transplant (alloSCT) with mobilized peripheral blood stem cell graft (PBSC; n = 508) versus bone marrow (BM) graft (n = 94; P Gray = .014; P Cox = .019). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Probability of chronic graft-versus-host disease (cGVHD) at 2 years after reduced-intensity conditioning (RIC) allogeneic stem cell transplant (alloSCT) with mobilized peripheral blood stem cell (PBSC) graft (n = 508) versus bone marrow (BM) graft (n = 94; P Gray = .04). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Probability of leukemia-free-survival (LFS) at 2 years after reduced-intensity conditioning (RIC) allogeneic stem cell transplant (alloSCT) with mobilized peripheral blood stem cell (PBSC) graft (n = 508) versus bone marrow (BM) graft (n = 94; P log-rank = .70; P Cox = .88). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions


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