1. Fig 6.1 Drug released by diffusion
Drug diffusion through additional polymer coating
Drug release by swelling of coating
Drug release by coating erosion
Polymer drug conjugate cleaved by hydrolysis or enzymic action
Biodegradable polymeric stent
Drug loaded in stent reservoir
Stent
Polymer
Drug
Fig 6.1

2. Thrombus organization Thrombus formation Anti-inflammatory drugs
SMC activation
Endothelial denudation
Vascular injury
Angioplasty
Proliferation DNA
synthesis
Restenosis
Extracellular matrix
formation
ECM modulators
Antiproliferative
agents
Thrombus organization
Thrombus formation
Anti-inflammatory
drugs
Negative arterial
remodeling
Migration
Antimigratory
Recoil
Mechanical stretch
Stent
Antiplatelet
therapy
Fig 6.2

3. Fig 6.3 Smooth muscle cells Tissue factor Cholesterol Necrotic core
Foam cells
Rupture of plaque
Platelets
Vascular endothelium
Atherosclerotic plaque
Vessel wall
Thrombus
Fig 6.3