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Infantile nephropathic cystinosis

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Presentation on theme: "Infantile nephropathic cystinosis"— Presentation transcript:

1 Infantile nephropathic cystinosis
M.B. Stokes, S. Jernigan, V.D. D'Agati  Kidney International  Volume 73, Issue 6, Pages (March 2008) DOI: /sj.ki Copyright © 2008 International Society of Nephrology Terms and Conditions

2 Figure 1 Glomerulus with multiple multinucleated podocytes and parietal epithelial cells (arrows) (hematoxylin and eosin stain; original magnification × 40). Kidney International  , DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions

3 Figure 2 Periodic acid–Schiff (PAS) reaction demarcates the glomerular basement membrane and highlights the visceral and parietal epithelial location of the multinucleated cells (arrows) (PAS; original magnification × 40). Kidney International  , DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions

4 Figure 3 High-power image of multinucleated visceral epithelial cell (arrow) (PAS reaction; original magnification × 60). Kidney International  , DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions

5 Figure 4 Interstitial histiocytes (brown stain) displaying cytoplasmic clefts and inclusions (CD68 immunoperoxidase stain; original magnification × 60). Kidney International  , DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions

6 Figure 5 Interstitial cells display cytoplasmic clear clefts consistent with crystalline inclusions (toluidine blue stain; original magnification × 100). Kidney International  , DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions

7 Figure 6 Interstitial cells containing multiple clear, elongated, needle-shaped and rhomboid cytoplasmic inclusions (electron photomicrograph; original magnification × 3000). Kidney International  , DOI: ( /sj.ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions


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