1. Sinus microbiota varies among chronic rhinosinusitis phenotypes and predicts surgical outcome 
Vijay R. Ramakrishnan, MD, Leah J. Hauser, MD, Leah M. Feazel, MS, Diana Ir, BS, Charles E. Robertson, PhD, Daniel N. Frank, PhD 
Journal of Allergy and Clinical Immunology 
Volume 136, Issue 2, Pages e1 (August 2015)
DOI: /j.jaci
Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
Sinus bacterial biodiversity in patient subsets. Differences in phylum- and genus-level RAs of 16S rRNA sequences are presented in terms of the presence of disease (A), asthma in patients with CRS (B), and purulence in patients with CRS (C). Bar charts depict the percentage of RAs of prominent phyla or genera with abundances of greater than 1.0%. Results of permutation-based multivariable ANOVA β diversity tests (R adonis function) are shown above the bar charts. •P < .1, *P < .05, and **P < .01. The right panels show PC plots based on genus-level bacterial classifications, as color coded by the presence of disease. The variance explained by PCoA axis 1 (PC1) was 24.7%, whereas PC2 explained an additional 17.1% of total variance.
Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci )
Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3. Fig 2
Sinus microbial diversity at the time of endoscopic surgery is prognostic of postoperative outcomes. A, Distribution of bacterial phyla in the sinuses of patients with CRS with suboptimal and optimal outcomes (only phyla with RAs >1.0% are shown). The box plot shows the RAs of Actinobacterium species in both postoperative outcome categories. B, Genus-level distributions in suboptimal and optimal outcomes (only genera with RAs >1.0% are shown). The box plot shows the RAs of Corynebacterium species in both postoperative outcome categories. C, Comparison of α diversity indices (richness, evenness, and Shannon diversity) between patients with suboptimal (Sub-opt.) and optimal (Opt.) postoperative outcomes.
Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci )
Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4. Fig E1
PCoA plot stratified by the presence or absence of allergic rhinitis. The plot of PC1 and PC2 presented in Fig 1 was color coded by the presence/absence of allergic rhinitis and asthma, as indicated in the legend. Although there is visually a rightward shift of nonasthmatic patients with CRS with allergic rhinitis, the associations were not statistically significant on either PC1 or PC2 scores.
Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci )
Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions