1. Prepared by Shafiqah | Husna | Fairoza | Fadhilah
HHV NUTRACEUTICAL FORMULATION TECHNOLOGY TYPE OF SUSPENDING AGENT
Prepared by
Shafiqah | Husna | Fairoza | Fadhilah

2. DEFINITION
Suspending agent excipient help active pharmaceutical active ingredient stay suspended in the formulation and prevent caking at the bottom of the container.
Properties:-
Easily re-suspended by the use of moderated agitation or shaking.

3. TYPE OF SUSPENDING AGENT
Natural agent
Inorganic salt
Synthetic compound

4. 1) Natural agent
The official suspending agents were natural polysaccharides but nowadays semi synthetic compounds are increasingly used.
Following are some examples of it:-
Acacia
Starch
Alginates
Xanthamn gums
Traganchants

5. Acacia Acacia Traganchant
Is dried exudates from Acacia senegal which occur as round ovoid colorless or white powder.
Not as good suspending agent but its protective colloidal property.
Used externally.
Acacia
As a thin, white or yellowish white, ribbon like flakes.
It forms viscous solutions.
Stable over pH 4 to 7.5
Used externally and internally.
Acacia
Traganchant

6. 2) Inorganic salts
Is the product of a reaction between hydrochloric acid and sodium hydroxide.
An organic salt is just any salt that doesn’t contain carbon.
Example:-
Clay
Bentonite
Aluminum magnesium silicate
Aluminium hydroxide

7. Magnesium aluminum silicate
Is subtype of montmorillionite clays, they hydrate readily absorbing up to 12 times their weight of water particularly at elevated temperatures.
The gels formed are thixotropic in nature so act as good suspending agent.
Insoluble flakes that disperse and swell readily in water.
Use internal and external
Stable at pH 3.5 to 11.
Bentonite
Magnesium aluminum silicate

8. 3) Synthetics Carbomer Colloidal silicon dioxide
These were introduced to over come various problems occurring from natural products.
Following are its examples:-
Carbomer
Colloidal silicon dioxide

9. Colloidal silicon dioxide
This material is totally copolymer of acrylic acid and allyl sucrose.
Used for external preparation.
pH between 6 to 11.
When dispersed in water they formed a three dimensional network.
It used as thickening agent for non aqueous suspension.
It obtain from silicon dioxide.
Cannot be easily dispersible.
Carbomer
Colloidal silicon dioxide

10. CONCLUSION
Suspending agent consist of 3 types which is natural agent, inorganic salt and synthetic compound.
Each types of suspending agents have their own function and examples.
Every type of suspending agent should have suitable pH to maintain their viscosity.