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Benefit of immediate revascularization in women with critical limb ischemia in an intention-to-treat analysis  Jana Ortmann, MD, Eveline Nüesch, PhD,

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Presentation on theme: "Benefit of immediate revascularization in women with critical limb ischemia in an intention-to-treat analysis  Jana Ortmann, MD, Eveline Nüesch, PhD,"— Presentation transcript:

1 Benefit of immediate revascularization in women with critical limb ischemia in an intention-to-treat analysis  Jana Ortmann, MD, Eveline Nüesch, PhD, Gian Cajöri, BS, Nicolas Diehm, MD, Florian Dick, MD, Tobias Traupe, MD, Iris Baumgartner, MD  Journal of Vascular Surgery  Volume 54, Issue 6, Pages e1 (December 2011) DOI: /j.jvs Copyright © 2011 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Decision flow chart.
Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Kaplan-Meier survival curves for cumulative outcome estimates of primary efficacy study end points for overall survival (left panels) and amputation-free survival (right panels) calculated separately for immediate revascularization and medical therapy (MT) with optional delayed revascularization for all patients irrespective of gender (upper panels), and separately for women (middle panels) and for men (lower panels). The P values were calculated using two-sided Wald test derived from Cox proportional hazard models. Numbers at risk are given for limbs. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Forest plots from univariable (left panels) and multivariable (right panels) Cox proportional hazard models that accounted for the clustering of limbs within patients to compare the effects of immediate revascularization vs medical therapy (MT) with optional delayed revascularization on overall survival (A), amputation-free survival (B), limb salvage (C), and sustained clinical success (D) separately for all patients, for female and for male patients. Multivariable Cox models were adjusted for age, diabetes, hypertension, smoking, renal failure, dialysis, hyperlipidemia, intake of anticoagulants or platelet inhibitors, and clinical symptoms according to Rutherford at baseline. The P values were calculated using two-sided Wald test derived from Cox proportional hazard models. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

5 Fig 4 Kaplan-Meier-survival curves for cumulative outcome estimates of immediate revascularization on efficacy study end point for amputation-free survival calculated separately for women and for men. The P values were calculated using two-sided Wald test derived from Cox proportional hazard models. Numbers at risk are given for limbs. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

6 Appendix Fig 5, online only
Forest plots from univariable (left panels) and multivariable (right panels) Cox proportional hazard models that accounted for the clustering of limbs within patients to compare the effects of endovascular (percutaneous transluminal angioplasty [PTA]) vs surgical (SURG) revascularization on overall survival (A and B) and amputation-free survival (C and D) separately for all patients, for female and for male patients. Multivariable Cox models were adjusted for age, diabetes, hypertension, smoking, renal failure, dialysis, hyperlipidemia, intake of anticoagulants or platelet inhibitors, and clinical symptoms according to Rutherford at baseline. The P values were calculated using two-sided Wald test derived from Cox proportional hazard models. CI, Confidence interval. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

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