1. CLASSIFICATION OF ANEMIAS

2. LEARNING OBJECTIVE
CLASSIFY ANAEMIAS

3. Chronic: GIT lesions,gynaecological disturbances
1. BLOOD LOSS
Acute: trauma
Chronic: GIT lesions,gynaecological disturbances
2. INCREASED RATE OF RED CELL DESTRUCTION
INTRINSIC ABNORMALITIES OF RED CELLS
Red cell membrane disorders
Hereditary spherocytosis
Red cell enzyme deficiences
G6PD deficiency

4. Disorders of haemoglobin synthesis
Quantitative defect of globin synthesis- Thalassemias
Qualitative defect of globin synthesis - Sickle cell anaemia
EXTRINSIC ABNORMALITIES OF RED CELLS
Antibody mediated
transfusion reactions Idiopathic Drug induced

5. Mechanical trauma to red cells Microangiopathic hemolytic anaemia
Thrombotic thrombocytopenia purpura
DIC
Severe vasculitis
CHEMICAL INJURY
Lead poisoning

6. 3.IMPAIRED RED CELL PRODUCTION
DISTURBANCE OF PROLIFERATION OF RED CELLS
Aplastic anaemia
DISTURBANCE OF MATURATION OF ERYTHROBLAST
Defective DNA Synthesis -Vitamin B12 and folate
Defective hemoglobin synthesis
Deficient heme synthesis- Iron deficiency anaemia
Deficient globin synthesis - Thalassemias

7. MATERIALS AND METHODS 50 patients of ALL
SAMPLE SIZE
50 patients of ALL
SAMPLING TECHNIQUE
Non probability purposive sampling

8. SPECIMEN COLLECTION Three ml venous blood in EDTA
Bone marrow aspirate in EDTA
Bone marrow aspiration smears
Genomic DNA was extracted from
blood/bone marrow

9. THANK YOU