1. Bioinformatics
Vicki
&
Joe

2. Goals and Project Plan Better Understand Human Genome Project
Computer Science and Molecular Biology
Bioinformatics Data Usage
Human Genome Project
-identify all genes in human DNA
-determine sequence of base pairs
-store information in databases
-improve tools for data analsys
Computer Science and Molecular Biology
-Find More links to Molecular Biology other than the basic definition of Bioinformatics
-We know they exist
- Pharmacutical industry and Gene Therapy
Bioinformatics Data Usage
-Understand what the data is used for after it is collected and cataloged into databases

3. Program Description Input: DNA Sequence Searches Sequence:
Base Pairs
Potential Gene
Pseudogene
Output: Potential Gene
Search BLAST Database
Program Searches for sequences of Base Pairs
Order Matters:
Starting Block: ATG
Ending Block:
Potential Gene:
- Greater Than 300
Pseudogene:
-Less Than 300
BLAST:
-Defined Later

4. Main Concepts Bioinformatics DNA -> RNA-> Protein
Replication -> Transcription -> Translation
Sequence Alignment
BLAST
Bioinformatics is the field of science in which biology, computer science, and information technology merge to form a single discipline. The ultimate goal of the field is to enable the discovery of new biological insights as well as to create a global perspective from which unifying principles in biology can be discerned.
DNA
-deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA
-Information stored as a code made up of four chemical bases: adenine (A), guanine (G), cytosine (C), and thymine (T).
(Our Program Searches DNA using these Bases
-The order of these bases determines the organisms make up.
-Every Cell Contains DNA
RNA
-Made up of chemical bases
-thymine(T) replaced by cytosine
-Is a copy of half the DNA strand (Transcription)
-Used to transport Information outside of cell for cell replication
Protein-
-Proteins perform important tasks for the cell functions or serve as building blocks.
-The flow of information from the genes determines the protein composition
-and thereby the functions of the cell.
Replication –
-Process of Copying DNA Sequence
Translation-
-Process of building protiens using RNA
Sequence Alignment-
of arranging the sequences of DNA, RNA, or protein to identify regions of similarity that may be a consequence of functional, structural, or evolutionary relationships between the sequences
BLAST-
-compares translational products of the nucleotide query sequence to a protein database
-This information is used to determine if there are and sequence alignments

5. References DNA-RNA-Protein Nobelprize.org Genetic Home Reference
ghr.nlm.nih.gov
A Science Primer
ncbi.nlm.nih.gov
Computer science and bioinformatics
Communications of the ACM
Volume 48 ,  Issue 3  (March 2005)