1. Volume 140, Issue 1, Pages 73-81.e5 (January 2011)
The PREMM1,2,6 Model Predicts Risk of MLH1, MSH2, and MSH6 Germline Mutations Based on Cancer History 
Fay Kastrinos, Ewout W. Steyerberg, Rowena Mercado, Judith Balmaña, Spring Holter, Steven Gallinger, Kimberly D. Siegmund, James M. Church, Mark A. Jenkins, Noralane M. Lindor, Stephen N. Thibodeau, Lynn Anne Burbidge, Richard J. Wenstrup, Sapna Syngal 
Gastroenterology 
Volume 140, Issue 1, Pages e5 (January 2011)
DOI: /j.gastro
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2. Figure 1
Receiver operating characteristic curves illustrating sensitivity and specificity of the PREMM1,2,6 model at different cutoffs for predicted probabilities.
Gastroenterology  , e5DOI: ( /j.gastro )
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3. Figure 2
(A–C) Gene-specific estimates provided by the PREMM1,2,6 model. Black boxes represent affected male subjects, black circles represent affected female subjects, white boxes represent unaffected male subjects, white circles represent unaffected female subjects, and arrows represent probands. EC, endometrial cancer; y, years.
Gastroenterology  , e5DOI: ( /j.gastro )
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4. Supplementary Figure 1
Final model for MLH1/MSH2/MSH6. The scatterplot diagram shows the added predictive value provided by the PREMM1,2,6 model in identifying MLH1 and MSH2 mutations based on the data from the current study. Compared with PREMM1,2, the extended model better predicts MLH1 and MSH2 gene mutations, as shown by more gene mutation carriers (Δ, MLH1; +, MSH2) above the line of identity (diagonal line) and nonmutation carriers (open circles) below the line of identity. The r coefficient of 0.94 indicates a high degree of overall agreement between the log odds of the model predictions.
Gastroenterology  , e5DOI: ( /j.gastro )
Copyright © 2011 AGA Institute Terms and Conditions

5. Supplementary Figure 2 Equations for PREMM1,2,6 model.
Gastroenterology  , e5DOI: ( /j.gastro )
Copyright © 2011 AGA Institute Terms and Conditions