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Protein Structure
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Biology/Chemistry of Protein Structure
Primary Secondary Tertiary Quaternary Assembly Folding Packing Interaction S T R U C T U R E P R O C E S S
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Primary Structure - Sequence
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FOLDING
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Basic Secondary structure
α-helix β-sheet Secondary structures, α-helix and β-sheet, have regular hydrogen-bonding patterns.
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1’ > 2’ > 3’ > 4’ > …
Tertiary structure Quaternary structure
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X - Ray X-ray Diffraction Pattern for a Protein
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X-Ray
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NMR – there is no right answer
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THE database of experimentally-derived structures of proteins, nucleic acids, and complexes
Access to structural information Visualization Analysis
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PDB Growth and Content Experimental Methods: Macromolecules:
X-Ray Crystallography NMR more… Macromolecules: Proteins Nucleic acids Carbohydrates Protein-nucleic acid complexes Protein-carbohydrate complexes
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PDB Homepage
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An Example – 2ARA
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Search Methods
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Advanced Search
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Sequence Search
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Example Results
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