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Combined Strategy Using Myoblasts and Hepatocyte Growth Factor in Dilated Cardiomyopathic Hamsters  Haruhiko Kondoh, MD, Yoshiki Sawa, MD, Norihide Fukushima,

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Presentation on theme: "Combined Strategy Using Myoblasts and Hepatocyte Growth Factor in Dilated Cardiomyopathic Hamsters  Haruhiko Kondoh, MD, Yoshiki Sawa, MD, Norihide Fukushima,"— Presentation transcript:

1 Combined Strategy Using Myoblasts and Hepatocyte Growth Factor in Dilated Cardiomyopathic Hamsters 
Haruhiko Kondoh, MD, Yoshiki Sawa, MD, Norihide Fukushima, MD, Goro Matsumiya, MD, Shigeru Miyagawa, MD, Satoru Kitagawa- Sakakida, MD, Yukiko Imanishi, Naomasa Kawaguchi, MD, Nariaki Matsuura, MD, Hikaru Matsuda, MD  The Annals of Thoracic Surgery  Volume 84, Issue 1, Pages (July 2007) DOI: /j.athoracsur Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Immunohistochemical staining for alpha- and beta-sarcoglycan. Representative photographs of immunohistochemical staining 2 weeks after the operation (A) and quantitative assessments of the alpha-sarcoglycan (B) and beta-sarcoglycan (C) signals are shown. Sections from age-matched F1B hamsters are shown in (A), and the quantitative results are expressed as the percentage of the signal strength normalized to F1B (n = 5 for each group, *p < 0.05). (C group = received culture medium alone; H group = received hemagglutinating virus of Japan [HVJ] liposomes containing hHGFcDNA; T group = received myoblasts; T+H group = received both myoblasts and HVJ liposomes containing hHGFcDNA.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Myocardial morphology of hamsters treated with myoblast transplantation and hepatocyte growth factor (HGF) transfection. (A) Hematoxylin and eosin (HE) and Masson’s trichrome staining of the myocardium from F1B hamsters and treated TO-2 hamsters 4 weeks after the operation. (B) Quantitative results of the fibrotic change in the left ventricle (n = 5 for each group, *p < 0.05). (C group = received culture medium alone; H group = received hemagglutinating virus of Japan [HVJ] liposomes containing hHGFcDNA; T group = received myoblasts; T+H group = received both myoblasts and HVJ liposomes containing hHGFcDNA.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Assessment of capillary density in the hearts of treated hamsters. (A) Representative staining for factor VIII in the myocardium 4 weeks after the operation. (B) Quantitative results of the density of arterioles and capillaries (n = 5 for each group, *p < 0.05). (C group = received culture medium alone; H group = received hemagglutinating virus of Japan [HVJ] liposomes containing hHGFcDNA; T group = received myoblasts; T+H group = received both myoblasts and HVJ liposomes containing hHGFcDNA.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

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