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Looping around Bcl6 in Germinal Center to Sharpen B Cell Immunity

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Presentation on theme: "Looping around Bcl6 in Germinal Center to Sharpen B Cell Immunity"— Presentation transcript:

1 Looping around Bcl6 in Germinal Center to Sharpen B Cell Immunity
Gangqing Hu, Keji Zhao  Immunity  Volume 45, Issue 3, Pages (September 2016) DOI: /j.immuni Copyright © Terms and Conditions

2 Figure 1 Multi-layer 3D Chromatin Reorganization during the Transition from Naive B Cells to GC B Cells Top: loss of interactions between p- and q-arms of a chromosome. Middle: merge of gene neighborhoods into gene “cities” with enhanced interactions among promotors and enhancers. Bottom: reorganization of 3D chromatin interactions centered on Bcl6 and an upstream LCR, accompanied by upregulation of GC-specific (GC-sp) transcription program. Immunity  , DOI: ( /j.immuni ) Copyright © Terms and Conditions


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