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Gastrointestinal Toxicity, Systemic Inflammation, and Liver Biochemistry in Allogeneic Hematopoietic Stem Cell Transplantation  Karina Jordan, Peter Pontoppidan,

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Presentation on theme: "Gastrointestinal Toxicity, Systemic Inflammation, and Liver Biochemistry in Allogeneic Hematopoietic Stem Cell Transplantation  Karina Jordan, Peter Pontoppidan,"— Presentation transcript:

1 Gastrointestinal Toxicity, Systemic Inflammation, and Liver Biochemistry in Allogeneic Hematopoietic Stem Cell Transplantation  Karina Jordan, Peter Pontoppidan, Hilde H. Uhlving, Katrine Kielsen, Douglas G. Burrin, Sarah Weischendorff, Ib J. Christensen, Marianne H. Jørgensen, Carsten Heilmann, Henrik Sengeløv, Klaus Müller  Biology of Blood and Marrow Transplantation  Volume 23, Issue 7, Pages (July 2017) DOI: /j.bbmt Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Alanine aminotransferase (ALT) levels at different time points from before conditioning, during the early engraftment phase after HSCT (days 0 to 21), at 3 months (days 80 to 100) after HSCT, and 6 months (days 160 to 200) after HSCT depicted as means with 95% CI. *Indicates a statistically significant difference in levels compared to baseline at day −7 (P < .05). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Bilirubin levels at different time points from before conditioning, during the early engraftment phase after HSCT (days 0 to 21), at 3 months (days 80 to 100) after HSCT, and 6 months (days 160 to 200) after HSCT depicted as means with 95% CI. *Indicates a statistically significant difference in levels compared to baseline day −7 (P < .05). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Plasma citrulline levels during HSCT. Citrulline levels depicted in boxplots at 3 different time points: day −7 pre-HSCT (baseline), day +7 after HSCT, and day +21 after HSCT. During the time period the citrulline concentrations decreased from baseline and subsequently increased *P < .0001. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions


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