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Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of.

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Presentation on theme: "Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of."— Presentation transcript:

1 Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-γ  Stephen R. Durham, MD, FRCPa, b, Sun Ying, PhDa, Veronica A. Varney, MB, MRCPa, Mikila R. Jacobson, PhDa, Robert M. Sudderick, FRCSb, Ian S. Mackay, FRCSb, A.Barry Kay, PhD, FRCPa, Qutayba A. Hamid, PhD MRCPa, c  Journal of Allergy and Clinical Immunology  Volume 97, Issue 6, Pages (June 1996) DOI: /S (96) Copyright © 1996 Mosby, Inc. Terms and Conditions

2 FIG. 1 Nasal symptom scores (median values and interquartile ranges) during early (0 to 60 minutes) and late (1 to 24 hours) responses after local nasal provocation with grass pollen in placebo-treated patients (open columns) and immunotherapy-treated patients (hatched columns). Levels of statistical significance (Mann-Whitney U test) are shown. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

3 FIG. 2 Cellular infiltration with CD4+ T lymphocytes, total (MBP+), and “activated” (EG2+) eosinophils 24 hours after nasal provocation with allergen and control (allergen diluent) solution. Horizontal bars represent median cell counts. The differences between counts 24 hours after allergen challenge minus control counts for placebo-treated (open circles) and immunotherapy-treated (filled circles) patients are compared by using the Mann-Whitney U test. Levels of statistical significance are shown. Within-group comparisons were performed with the Wilcoxon test. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

4 FIG. 3 In situ hybridization of nasal biopsy specimens with an antisense riboprobe against mRNA for IFN-γ. The difference in mRNA+ cell counts (24 hours after allergen challenge minus counts 24 hours after a control challenge with allergen diluent) for placebo-treated (open circles) and immunotherapy-treated (filled circles) patients were compared by using the Mann-Whitney U test. Within-group comparisons were performed by using the Wilcoxon test. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

5 FIG. 4 Autoradiographs of cryostat sections of nasal biopsy specimens 24 hours after local allergen provocation from patients treated with placebo (A) and patients treated with immunotherapy (B). Sections were hybridized with a 35S-labeled antisense IFN-γ probe. Autoradiographs of sections of nasal biopsy specimens from a patient treated with immunotherapy hybridized with a 35S-labeled sense IFN-γ probe (C) and positive control of phytohemagglutinin-stimulated blood mononuclear cells that express mRNA for IFN-γ (D). Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

6 FIG. 4 Autoradiographs of cryostat sections of nasal biopsy specimens 24 hours after local allergen provocation from patients treated with placebo (A) and patients treated with immunotherapy (B). Sections were hybridized with a 35S-labeled antisense IFN-γ probe. Autoradiographs of sections of nasal biopsy specimens from a patient treated with immunotherapy hybridized with a 35S-labeled sense IFN-γ probe (C) and positive control of phytohemagglutinin-stimulated blood mononuclear cells that express mRNA for IFN-γ (D). Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

7 FIG. 4 Autoradiographs of cryostat sections of nasal biopsy specimens 24 hours after local allergen provocation from patients treated with placebo (A) and patients treated with immunotherapy (B). Sections were hybridized with a 35S-labeled antisense IFN-γ probe. Autoradiographs of sections of nasal biopsy specimens from a patient treated with immunotherapy hybridized with a 35S-labeled sense IFN-γ probe (C) and positive control of phytohemagglutinin-stimulated blood mononuclear cells that express mRNA for IFN-γ (D). Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

8 FIG. 4 Autoradiographs of cryostat sections of nasal biopsy specimens 24 hours after local allergen provocation from patients treated with placebo (A) and patients treated with immunotherapy (B). Sections were hybridized with a 35S-labeled antisense IFN-γ probe. Autoradiographs of sections of nasal biopsy specimens from a patient treated with immunotherapy hybridized with a 35S-labeled sense IFN-γ probe (C) and positive control of phytohemagglutinin-stimulated blood mononuclear cells that express mRNA for IFN-γ (D). Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

9 FIG. 5 Relationship between allergen-induced IFN-γ mRNA+ cells in the nasal mucosa of immunotherapy-treated patients and seasonal hay fever symptoms (area under curve) and medication (topical cromolyn sodium applied to nose and eyes and oral antihistamine [acrivastine] tablets) during the 11-week pollen season. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

10 FIG. 5 Relationship between allergen-induced IFN-γ mRNA+ cells in the nasal mucosa of immunotherapy-treated patients and seasonal hay fever symptoms (area under curve) and medication (topical cromolyn sodium applied to nose and eyes and oral antihistamine [acrivastine] tablets) during the 11-week pollen season. Journal of Allergy and Clinical Immunology  , DOI: ( /S (96) ) Copyright © 1996 Mosby, Inc. Terms and Conditions

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